Results:In a total of 125 patients, there were no significant differences in clinical presentation by sex.
The initial self-misdiagnosis rates for men and women were 10% and 18%, respectively (P = NS).
Among the 62 patients with a serologic test as part of their clinical evaluation:
• 50% of men had a positive, 2-tier result
• Compared with 32% of women (P = NS).
Among the 41 patients with a positive ELISA, median ELISA values (3.4 vs 2.0; P = 0.03) and median number of immunoglobulin G (IgG) bands (4 vs 2; P = 0.03) were significantly higher among men.
Conclusions:In this small, retrospective sample, we found evidence for sex-based differences in the magnitude of ELISA and IgG serologic response to early Lyme disease.
Such differences could have implications for appropriate diagnosis, treatment, and disease classification.
Larger, prospective studies are needed to replicate the results found in this study and to examine their relationship to sex-based immunologic variability.
Source:Gender Medicine, Aug 2010;7(4):320-9. PMID: 20869632, by Schwarzwalder A, Schneider MF, Lydecker A, Aucott JN.The Lyme Disease Research Foundation of Maryland, Lutherville, Maryland, USA.
Anti-C. pneumoniae antibodies, obtained commercially, identified both typical intracellular and atypical extracellular C. pneumoniae antigens in frontal and temporal cortices of the AD brain. C. pneumoniae, amyloid deposits, and neurofibrillary tangles were present in the same regions of the brain in apposition to one another. Although additional studies are required to conclusively characterize the nature of Chlamydial immunoreactivity in the AD brain, these results further implicate C. pneumoniae infection with the pathogenesis of Alzheimer’s disease
The protozoan parasiteTheileriainhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis. The transforming schizont is a multinucleated syncytium that resides free in the host cell cytoplasm and is strictly intracellular. To maintain transformation, it is crucial that this syncytium is divided over the two daughter cells at each host cell cytokinesis. This process was dissected using different cell cycle synchronization methods in combination with the targeted application of specific inhibitors. We found thatTheileriaschizonts associate with newly formed host cell microtubules that emanate from the spindle poles, positioning the parasite at the equatorial region of the mitotic cell where host cell chromosomes assemble during metaphase. During anaphase, the schizont interacts closely with host cell central spindle. As part of this process, the schizont recruits a host cell mitotic kinase, Polo-like kinase 1, and we established that parasite association with host cell central spindles requires Polo-like kinase 1 catalytic activity. Blocking the interaction between the schizont and astral as well as central spindle microtubules prevented parasite segregation between the daughter cells during cytokinesis. Our findings provide a striking example of how an intracellular eukaryotic pathogen that evolved ways to induce the uncontrolled proliferation of the cells it infects usurps the host cell mitotic machinery, including Polo-like kinase 1, one of the pivotal mitotic kinases, to ensure its own persistence and survival.
Experienced physicians have used massive amounts of vitamin C and other nutrients in treating an astonishing and nearly unbelievable variety of conditions. “Many physicians refuse to employ Vitamin C in the amounts suggested,” writes Dr. Klenner, “simply because it is counter to their fixed ideas of what is reasonable. There is no doubt that physicians are being brainwashed with the current journal advertising. I have never seen a patient that Vitamin C would not benefit.”
Dr. Klenner was board certified in diseases of the chest. The Shutes, in obstetrics. Dr. Cathcart, in orthopedic surgery. Dr. Smith, in pediatrics. Dr. Riordan, in psychiatry. Dr. Cameron, in surgery.
What you will learn from the documents above may be a good start, but it is only a start. We recommend that you read extensively and then discuss these physicians’ experience with your doctor before making any health decision.
Borrelia burgdorferi, the agent of Lyme borreliosis, has the ability to undergo morphological transformation from a motile spirochetal to non-motile spherical shape when it encounters unfavorable conditions. However, little information is available on the mechanism that enables the bacterium to change its shape and whether major components of the cells – nucleic acids, proteins, lipids – are possibly modified during the process.
Deducing from investigations utilizing electron microscopy, it seems that shape alteration begins with membrane budding followed by folding of the protoplasmatic cylinder inside the outer surface membrane. Scanning electron microscopy confirmed that a deficiency in producing functioning periplasmic flagella did not hinder sphere formation. Further, it was shown that the spirochetes’ and spheres’ lipid compositions were indistinguishable. Neither phosphatidylcholine nor phosphatidylglycerol were altered by the structural transformation. In addition, no changes in differential protein expression were detected during this process. However, minimal degradation of RNA and a reduced antigen-antibody binding activity were observed with advanced age of the spheres.
Dr. Gordon’s influential and breakthrough webinars are finally available, right here, on Linda’s blog! Watch the first (and most important) webinar below, then click here to watch the rest of the webinars.
Synthetic sex hormones (Environmental Estrogens) are contaminating our food! Now you will know why it is so hard to get your patients well without an all organic diet and my detox program. The link to the news broadcast below will shock you. For instance, did you know…
Bisphenol A is found in most plastic food containers today. Not only is it found in plastic containers, but also in the lining of most cans. BPA is essentially a synthetic estrogen that enters the body when one consumes food or beverages out of plastic or plastic-lined containers. This is not only harmful to the male reproductive system, but has been found to also stimulate breast cancer growth in women. Knowing this, it should be of no surprise that the sperm count of the average Western male is on a steady decline as many males are becoming more and more feminine. What most people don’t know is that Bisphenol A was actually considered as the form of estrogen to be used in estrogen pills going back to the 1930s.
Everyone should detox regularly and continually on a daily basis. Everyone needs my F.I.G.H.T. program! It is not just the Lead and Mercury; it is toxins like Bisphenol A but most people have no idea how they get these toxins! Bisphenol A is what made all the lean brown Agouti mice turn yellow and become obese and diabetic for all time in Randy Jirtle’s research (Duke) covered by PBS (Nova) as “Ghost In Your Genes” that causes the epigenetic change overnight.
There is defective methylation to handle all toxins, which is why BIOEN’R-G’Y C comes with Trimethylglycine and Methylsulfonomethane, as a true vitamin C delivery system to help fight this Bisphenol A toxin induced need for more methylation support. So get sublingual Beyond B12 and have methyl cobalamin delivered sublingually instead of having to give B12 IM, as oral B12 is about 1-2 % absorbed and we must help our loved ones and patients F.I.G.H.T. back.
Everyone has 10,000 times more phthalates today than was present just 10 years ago. Watch this video and then watch it again and learn my F.I.G.H.T. program, as you and your patients need to feel as good as I do and I know how toxic you are unless you are using my power drink and zeolite!
Dr. Garry Gordon discusses Infections believed to be a contributing part of all cancers. Discover how natural supplements such as Zeolite, Vitamin C, Silver and EDTA help to remove cancer-causing toxins. Only when we are successful in lowering the total body burden of toxins and infections can we begin to win the war against cancer and all other degenerative diseases.
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