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Calcium Supplements & Cardiovascular Events

Please stop patients from using massive doses of calcium now. The patients all have too much calcium in vascular tissue and now we have data showing that giving calcium is increasing heart disease. And, if possible, try to always administer calcium supplementation with EQUAL AMOUNTS of MAGNESIUM, as I have been teaching for over 20 years now.

Also please realize I use calcium in well over 90 % of my patients. It is in BAM, my multiple called Beyond Any Multiple. I usually never use more than 500 mg of calcium a day for my long-term patients, as that is all most will need since that is the amount we need to offset the excess of phosphorus over calcium in the American diet. This amount will help lower the tendency for the body to develop secondary hyperparathyroidism, which is how the body responds to a chronic dietary intake of more phosphorus than calcium.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com 

Excerpt:
Results 15 trials were eligible for inclusion, five with patient level data (8151 participants, median follow-up 3.6 years, interquartile range 2.7-4.3 years) and 11 with trial level data (11 921 participants, mean duration 4.0 years). In the five studies contributing patient level data, 143 people allocated to calcium had a myocardial infarction compared with 111 allocated to placebo (hazard ratio 1.31, 95% confidence interval 1.02 to 1.67, P=0.035). Non-significant increases occurred in the incidence of stroke (1.20, 0.96 to 1.50, P=0.11), the composite end point of myocardial infarction, stroke, or sudden death (1.18, 1.00 to 1.39, P=0.057), and death (1.09, 0.96 to 1.23, P=0.18). The meta-analysis of trial level data showed similar results: 296 people had a myocardial infarction (166 allocated to calcium, 130 to placebo), with an increased incidence of myocardial infarction in those allocated to calcium (pooled relative risk 1.27, 95% confidence interval 1.01 to 1.59, P=0.038). 

Conclusions Calcium supplements (without coadministered vitamin D) are associated with an increased risk of myocardial infarction. As calcium supplements are widely used these modest increases in risk of cardiovascular disease might translate into a large burden of disease in the population. A reassessment of the role of calcium supplements in the management of osteoporosis is warranted.

Curcumin: the Indian solid gold

Cancer therapies should include high quality absorbable curcumin, as it provides the same effects as standard chemo does!

Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease, and other chronic illnesses.

These effects are mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinesis, and other enzymes. Curcumin exhibits activities similar to recently discovered tumor necrosis factor blockers (e.g., HUMIRA, REMICADE, and ENBREL), a vascular endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2 blocker (e.g., HERCEPTIN).

Considering the recent scientific bandwagon that multi-targeted therapy is better than mono-targeted therapy for most diseases, curcumin can be considered an ideal “Spice for Life”.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Full article: http://www.ncbi.nlm.nih.gov/pubmed/17569205?dopt=Citation

Excerpt:

Turmeric, derived from the plant Curcuma longa, is a gold-colored spice commonly used in the Indian subcontinent, not only for health care but also for the preservation of food and as a yellow dye for textiles. Curcumin, which gives the yellow color to turmeric, was first isolated almost two centuries ago, and its structure as diferuloylmethane was determined in 1910. Since the time of Ayurveda (1900 Bc) numerous therapeutic activities have been assigned to turmeric for a wide variety of diseases and conditions, including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and liver disorders. Extensive research within the last half century has proven that most of these activities, once associated with turmeric, are due to curcumin. Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease, and other chronic illnesses. These effects are mediated through the regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other enzymes. Curcumin exhibits activities similar to recently discovered tumor necrosis factor blockers (e.g., HUMIRA, REMICADE, and ENBREL), a vascular endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2 blocker (e.g., HERCEPTIN). Considering the recent scientific bandwagon that multitargeted therapy is better than monotargeted therapy for most diseases, curcumin can be considered an ideal “Spice for Life”.

PCR amplification of Bartonella koehlerae

Full article: http://www.parasitesandvectors.com/content/pdf/1756-3305-3-76.pdf

Excerpt:

Cats appear to be the primary reservoir host for Bartonella koehlerae, an alpha Proteobacteria that is most likely transmitted among cat populations by fleas (Ctenocephalides felis). Bartonella koehlerae has caused endocarditis in a dog and in one human patient from Israel, but other clinically relevant reports involving this bacterium are lacking. Despite publication of numerous, worldwide epidemiological studies designed to determine the prevalence of Bartonella spp. bacteremia in cats, B. koehlerae has never been isolated using conventional blood agar plates. To date, successful isolation of B. koehlerae from cats and from the one human endocarditis patient has consistently required the use of chocolate agar plates.

Results

In this study, Bartonella koehlerae bacteremia was documented in eight immunocompetent patients by PCR amplification and DNA sequencing, either prior to or after enrichment blood culture using Bartonella alpha Proteobacteria growth medium. Presenting symptoms most often included fatigue, insomnia, joint pain, headache, memory loss, and muscle pain. Four patients were also infected with Bartonella vinsonii subsp. berkhoffii genotype II. After molecular documentation of B. koehlerae infection in these patients, a serological test was developed and serum samples were tested retrospectively. Bartonella koehlerae antibodies were not detected (titers< 1:16) in 30 healthy human control sera, whereas five of eight patient samples had B. koehlerae antibody titers of 1:64 or greater.

Aspartame Symptoms Submitted to the FDA

The following are symptoms attributed to aspartame in complaints submitted to the FDA by the Department of Health and Human Services April 20, 1995.

Additional Comment from Betti Martini (Posted: 16 April 2007)

As many may know, aspartame is on the market illegally. It’s 
adulterated as discussed by the National Soft Drink Assn (now 
American Beverage) and in the congressional record. 
http://www.wnho.net/congressional_record1.doc 
Because you cannot ship an adulterated product for sale it, 
therefore, violates Interstate Commerce. Dr. Adrian Gross, FDA 
toxicologist, told Congress that aspartame violated the Delaney 
Amendment which forbids putting anything in food that caused cancer 
in animals. 
http://www.wnho.net/whopper.htm It’s 
also a drug, an addictive excitoneurotoxic carcinogenic drug that 
interacts with all drugs and vaccines, and is masquerading as an 
additive. Additives by law must be inert or non-reactive. Inert 
products do not produce a list of 92 documented symptoms from 4 types 
of seizures to coma and death, nor necessitate a 1038 page medical 
text. (Aspartame Disease: An Ignored Epidemic, H. J. Roberts, M.D., 
www.sunsentpress.com or 1 800 827 7991.) Nor would consumers using 
this product need to be detoxed. “What To Do If You Have Used 
Aspartame” by neurosurgeon Russell Blaylock, M.D., 
http://www.wnho.net/wtdaspartame.htm

Here is the Board of Inquiry Report of the FDA revoking the petition 
for approval of aspartame, after it kept it off the market many years 
and they attempted to have the manufacturer, Searle, indicted for 
fraud. 
<http://www.wnho.net/fda_petition1.doc>http://www.wnho.net/fda_petition1.doc 
Note in the commentary above it is a clip from Sweet Misery: A 
Poisoned World, <http://www.amazon.com>http://www.amazon.com, James 
Turner, Washington, D.C., attorney explains how Donald Rumsfeld who 
was then CEO of Searle called in his markers and got aspartame, this 
deadly poison, on the market for human consumption.

Here are the 92 the FDA agreed were symptoms for aspartame. However, 
there are many more in Dr. Roberts medical text:

Headache
Dizziness or Problems with Balance
Change in Mood Quality or Level
Vomiting and Nausea
Abdominal Pain and Cramps
Change in Vision
Diarrhea Seizures and Convulsions
Memory Loss
Fatigue, weakness
Other neurological
Rash
Sleep problems
Hives
Change in Heart Rate
Itching
Change in Sensation (Numbness, Tingling)
Grand Mal
Local Swelling
Change in Activity Level
Difficulty Breathing
Oral Sensory Changes
Change in Menstrual Pattern
Other Skin
Other Localized Pain and Tenderness
Other Urogenital Change in Body Temperature
Difficulty Swallowing
Other Metabolic Joint and Bone Pain
Speech Impairment
Other Gastrointestinal
Chest Pain
Other Musculo-Skeletal
Fainting
Sore Throat
Other Cardiovascular
Change in Taste
Difficulty with Urination
Other Respiratory
Edema
Change in Hearing
Abdominal Swelling
Change in Saliva Output
Change in Urine Volume
Change in Perspiration Pattern
Eye Irritation
Unspecified
Muscle Tremors
Petit Mal
Change in Appetite
Change in Body Weight
Nocturnal
Change in Thirst or Water Intake
Unconsciousness and Coma
Wheezing
Constipation
Other Extremity
Pain
Problems with Bleeding
Unsteady Gait
Coughing Blood
Glucose Disorders
Blood Pressure Changes
Changes in Skin and Nail Coloration
Change in hair or nails
Excessive phlegm Production
Sinus Problems Simple
Partial Seizures
Hallucinations
Any Lumps Present
Shortness of Breath on Exertion
Evidence of Blood in Stool or Vomit
Dysmenorrhea
Dental Problems
Change in smell
DEATH
Other Blood and Lymphatic
Eczema
Complex Partial Seizures
Swollen Lymph Nodes
Hematuria
Shortness of Breath Due to Position
Difficulties with Pregnancy
(Children Only) Developmental Retardation
Change in Breast Size or Tenderness
Anemia
Change in Sexual Function
Shock
Conjunctivitis
Dilating Eyes
Febrile

_______________________________________________

Several people have asked for this list so they could forward it to 
the media when the manufacturers, front groups and professional 
organizations funded by the manufacturers put propaganda in the 
press. Even the FDA has lied about the existence of this report. I do 
have it on FDA stationery, which I have faxed to the press many times 
when they tried to deny it. This report was gotten through Freedom of 
Information.

If you do forward this to the press be sure you always include the 
Diane Fleming story who is in Sweet Misery: A Poisoned World, and the 
Artificially Sweetened Times (www.idaho-observer.com). Her husband 
died from methanol poisoning from aspartame and she was convicted of 
poisoning him even after passing 3 lie detector tests, and was the 
one who called the police because she didn’t know aspartame liberates 
free methyl alcohol. 
<http://www.namastepublishing.co.uk/Diane%20Fleming%20Story%20.htm>http://www.namastepublishing.co.uk/Diane%20Fleming%20Story%20.htm 
Also we are taking aspartame brain tumor cases in New York and New Jersey.

Safe Alternatives: Stevia and Just Like Sugar (Whole Foods and Wild Arts).

All my best,

Dr. Betty Martini
Founder, Mission Possible World Health International
9270 River Club Parkway
Duluth, Georgia 30097
770-242-2599
E-Mail: <mailto:BettyM19@mindspring.com>BettyM19@mindspring.com
http://www.wpwhi.com
<http://www.whno.net>http://www.whno.net
http://www.dorway.com

Aspartame Toxicity Center: 
<http://www.holisticmed.com/aspartame>http://www.holisticmed.com/aspartame

<http://www.mpwhi.com/articles-bmartini.htm>
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ublic Relations Campaign Deception: Aspartame & Formaldehyde

Full article: http://www.holisticmed.com/aspartame/

Excerpt:

I have recently been sent some information about aspartame and formaldehyde that looks like it might be part of one last public relations campaign to claim the chemical is ’safe’. The formaldehyde exposure number cited in the text is off by a factor of over 400,000 and would not be taken seriously by knowledgeable scientists. The scientific literature cited has clearly not been read by the author. However, since a few consumers might inadvertently take the text seriously, I have chosen to point out some of the more obvious problems with the text.

> A simple MEDLINE search reveals that the levels of 
> formaldehyde they are talking about (30 micrograms after the 
> ingestion of 200 mg/kg/day of aspartame for 11 days) are 
> well within ’safe’ levels, even though 200 mg/kg is equal to 
> about 60 Diet Cokes per day(!). 

The truth is that there is no MEDLINE summary showing an exposure to or an accumulation of 30 micrograms (ug) of formaldehyde in humans after ingestion of 200 mg/kg/day of aspartame. This figure appears to be either fabricated or caused by some serious math errors. The actual figure can be calculated quite easily and is approximately 61.3 milligrams (mg) for ingestion of one liter of diet soda.

The actual measured amount of aspartame in one liter of diet soda is approximately 600 mg. [Ref. 1]. If a 60 kg (132 lbs) woman ingested one liter of diet soda, she would be ingesting 10 mg/kg of aspartame:

    600 mg aspartame / 60 kg body weight = 10 mg/kg

Aspartame breaks down into 10.9% methanol by weight [Ref. 2]. So that the amount of methanol obtained from 600 mg of aspartame is:

    600 mg aspartame * 10.9% = 65.4 mg of methanol

Discovery of Chronic Pain Gene

Full article: http://genome.cshlp.org/content/early/2010/08/02/gr.104976.110.abstract

Excerpt:

Chronic pain is a serious medical problem, afflicting approximately 20% of adults. Some individuals are more susceptible than others, and the degree of pain experienced after injury or surgery is known to be highly variable between patients, even under nearly identical circumstances.

The basis for this has remained largely unknown, prompting researchers to search for the contribution of genetics to chronic pain susceptibility. To accelerate research in this field, animal models are proving to be critical to understanding the underlying biology of chronic pain in human patients.

First, the international research team - led by Profs. Ariel Darvasi and Marshall Devor at The Hebrew University of Jerusalem and including scientists in Canada and Europe - identified a region of mouse chromosome 15 that likely contained a genetic variant or variants contributing to pain. 

Topical drug for Bartonella prevention?

Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20392182&retmode=ref&cmd=prlinks

Excerpt:

Conclusions and Clinical Relevance-In this setting, monthly
topical administration of 10% imidacloprid-1% moxidectin reduced
flea infestation, compared with infestation in untreated cats,
and thus prevented flea transmission of B henselae to treated
cats. Regular monthly use of this flea control product in cats
may lessen the likelihood of humans acquiring B henselae
infection.

Hypothyrodism and endothelial dysfunction - a message from Dr. Gordon

This mainstream report found that one year of Levothyroxine treatment does not fully restore endothelial function. This is important for two reasons: 
1. Mainstream is beginning to acknowledge that low thyroid functioning contributes to heart disease.
2. Also I suggest that Heart Disease is multifactorial and, therefore, MONOTHERAPY will often fail. 

Many would feel that the type of thyroid replacement is a partial explanation but I feel that we would need to look at Iodine to have provided a better outcome. But all the elements of my FIGHT program are relevant for those seeking OPTIMAL improvement in cardiac or endothelial function. There is always low levels of some nutrients (F), take your pick from Vit D to Magnesium. There will always be the high probability of CMV infection (I). And, probably some Genetic issues with some epigenetic changes increasing the need for methylation support including the active forms of Folic Acid (G). Then there will always be some element of heavy metals (H: Lead, etc.) and there will be Toxins in everyone that include endocrine disruptors and neurotoxins (T)!

Thus this report should help prove the need for broadly based approaches in dealing with chronic illness such as endothelial dysfunction leading to atherosclerosis.

Garry F Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com  

Full article: http://www.ingentaconnect.com/content/bsc/cend/2009/00000070/00000006/art00017

Excerpt:

Abstract:
 Summary Objective 
Hypothyroidism is associated with elevated cardiovascular risk, not fully explained by classical risk factors. Instead, endothelial dysfunction may link hypothyroidism to atherosclerosis. The effect of levothyroxine substitution on endothelial function has been sparsely studied and the results are unclear. This study tested endothelial function as estimated by concomitant measurements of endothelial dependent vascular dilatory capacity and plasma concentration of von Willebrand factor antigen in patients with hypothyroidism and further examined  the impact of subsequent levothyroxine substitution.

Legal issues and aggressive Lyme disease therapy - a victory!

Full article: http://www.bostonherald.com/business/healthcare/view.bg?articleid=1268561&srvc=rss

Excerpt:

A new state law that spells out the rights of physicians to treat chronic Lyme disease patients with long-term antibiotics is being heralded as a victory by advocates of people afflicted by the tick-borne illness, reports the Cape Cod Times.

The law is meant to prevent doctors who treat patients with antibiotics beyond the 30 days recommended by some professionals from billing insurance, said Brenda Boleyn, who chairs the Cape and Islands Lyme Disease Task Force, a community organization comprised of local government, agencies and Lyme disease patients.

While short courses of antibiotics appear to work when Lyme is detected in its early stages, more aggressive and longer treatment seems to be the only solution for seemingly intractable cases of Lyme, Boleyn said.

Aerobic Exercise Testing in Clinical Practice

Stress ECG pales in comparison to www.PREMIERHEART.com. Multigate ECG requires a $35,000 advanced computerized painless 15 minute ECG but has real predictive value that you can use to motivate patients to stay on my protocol and virtually eliminate all fatal heart attacks.

The statements you can make about the badly outdated stress ECG is that it has some limited usefulness. Investing in the future moves this into meaningful predictive medicine.

Here is a statement from the proponents of the outdated stress ECG that are unwilling to move into the future and use multigated ECG from www.premierheart.com. Anyone can have this test in a cardiologist’s office in Tucson, AZ for $150 cash. That is the logical next step in testing anyone with a real desire to know the status of their coronaries better than angiograms non-invasively and quickly.

Here is the data from the attached report on stress ECG, clearly better than nothing but not very predictive. The $1000 www.bioclip.com vascular age test tells us that those who do poorly have a 90% probability they will be dead within ten years!

Here is what you might learn from a treadmill ECG. Low aerobic capacity in young adulthood appears to predict a higher likelihood of established cardiovascular risk factors later in life. Carnethon et al. performed aerobic exercise testing in more than 4000 apparently healthy males and females between 18 and 30 years of age.[95] There was an increasing risk for the development of hypertension, diabetes and metabolic syndrome with a progressively lower aerobic capacity during the 15 year follow-up, which was maintained after adjusting for baseline body mass index.

Also here is the link for those of you who couldn’t open it to yesterday’s article:http://www.scribd.com/doc/35263197/Dumbing-Down-Part-I

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Full article: http://www.medscape.com/viewarticle/722941_2

Excerpt:

The four traditional vital signs: resting heart rate, blood pressure, respiratory rate and body temperature, serve as the cornerstone of a physical examination. Other assessments such as pain have been proposed as additional vital signs. To this point however, there has been limited consideration for aerobic exercise assessment as a vital sign. A wealth of literature demonstrating the prognostic, diagnostic and interventional value of the aerobic exercise assessment now exists, supporting its use in numerous clinical scenarios. Moreover, the assessment of the aerobic exercise response allows for the manifestation of physiologic abnormalities that are not readily apparent during the collection of resting data. This review will provide evidence supporting the assertion that the aerobic exercise assessment may be afforded vital sign status in future clinical practice.