All Posts Tagged With: "allergy"

Excerpt:

We describe a 37-year-old woman who presented with bilateral pleural effusion combined with intermittent low grade fever. Lyme disease was confirmed by seroreactivities against Borrelia burgdorferi spirochetes. The unique clinical findings reveal a rare manifestation with a possible association between B. burgdorferi infection and pleural effusion.

Central Role of the Holliday Junction Helicase RuvAB in vlsE Recombination and Infectivity of Borrelia burgdorferi

Lyme disease is the most prevalent tick-borne infection in North America and Eurasia. It is caused by the bacterium Borrelia burgdorferi and is transmitted to humans via the bite of infected ticks. These spirochetes can cause both acute and chronic infection and inflammation of the skin, joints, heart, and central nervous system. The persistence of infection despite the presence of an active immune response is dependent upon antigenic variation of VlsE, a 35 kDa surface-exposed lipoprotein. A large number of different VlsE variants are present in the host simultaneously and are generated by recombination of the vlsE gene with adjacent vls silent cassettes. To try to identify factors important in vlsE recombination and immune evasion, we selected mutants in genes involved in DNA recombination and repair and screened them for infectivity and vlsE recombination. Mutants in genes encoding RuvA and RuvB (which act together to promote the exchange of strands between two different DNA molecules) had reduced infectivity and greatly diminished vlsE recombination. In immunodeficient mice, ruvA mutants retained full infectivity, and no vlsE recombination was detected. Our findings reinforce the importance of vlsE variation in immune evasion and persistent infection. Continued

To delineate the inflammatory potential of the 3 pathogenic species of Borrelia burgdorferi sensu lato, we stimulated monocyte-derived macrophages from healthy human donors with 10 isolates each of B. burgdorferi, Borrelia afzelii, or Borrelia garinii recovered from erythema migrans skin lesions of patients with Lyme borreliosis from the United States or Slovenia. B. burgdorferi isolates from the United States induced macrophages to secrete significantly higher levels of interleukin (IL)-8, CCL3, CCL4, IL-6, IL-10, and tumor necrosis factor than B. garinii or B. afzelii isolates. Consistent with this response in cultured macrophages, chemokine and cytokine levels in serum samples of patients from whom the isolates were obtained were significantly greater in B. burgdorferi-infected patients than in B. afzelii- or B. garinii-infected patients. These results demonstrate in vitro and in vivo that B. burgdorferi has greater inflammatory potential than B. afzelii and B. garinii, which may account in part for variations in the clinical manifestations of Lyme borreliosis. Continued

Linda’s Comment:  It amazes me that in the following publications do we find any suggestions about reducing our total body burden of pathogens and toxins.  It is a MUST that Lymies begin to reduce their total body burden of pathogens and toxins in order to begin addressing Lyme, Lyme Arthritis, Arthritis, and other chronic illness we see with Lyme patients.  Some people choose antibiotics…..I personally never went near antibiotics.  My whole detox and healing program was using anti-microbials, alternative medicine, alternative modalities, NO GMO foods, NO sugars, NO fast foods, NO soda’s, NO caffeine, NO coffee and I ate and still do eat organic foods.  I also have used a PhotonGenie since 2001 and use it daily.  I like it better than Rife, as I don’t have to worry about settings, I just turn it on and go.  I even sleep in mine.  The critters we Lymies fight LOVE heavy metals and especially GMO foods.  
 
There are also some foods that you don’t want to eat if you are having symptoms of Arthritis, however, it is more important to get rid of the GMO, sugars, coffee and soda’s to reduce the inflammation and pain.  The great thing about the fight program is you are dissolving biofilms and reducing inflammation on a daily basis.  So much of our pain comes from inflammation. 
 
I of course use many more things with my lifelong daily detox protocol.  If you can get IV chelation and do weekly colonics you can move things along faster.  However, you can start the program one step at a time and move at your own pace.  This is one protocol that must be done as suggested to get the full benefit of wellness.  The first three months are your toughest, but after that it is a breeze.  Yes, ever so often you have a day or two like you did when you first started, but I tell folks, it is like peeling an onion.  As you reach a new level you will have a couple of days where you keep your bathroom close.  At the end of 60 to 90 days and you begin to feel your life coming back to you, you will be very pleased that you began this journey.  Feel free to ask questions and I will share my journey with you.  Just remember JUST SAY NO TO GMO!! Continued