All Posts Tagged With: "ceftriaxone"

Full article: http://sci.tech-archive.net/Archive/sci.med.diseases.lyme/2008-06/msg00078.html

Excerpt:

IDSA knows that chronic Lyme exists

The IDSA is aware that chronic Lyme exists. We know this because
members of the 2000 and 2006 Lyme disease guideline panels wrote, in
research articles and patents, that chronic Lyme exists.

Evidence about the existence of chronic Lyme borreliosis has increased
since the 2006 LD guidelines were published.

Scientists in California recently reported that not only can Bb persist
in mice despite treatment with ceftriaxone, but the Borrelia can also
infect other ticks and mice. (1) This study buttresses previous
studies that showed that Borrelia can persist in mice (2, 3), dogs (4,
5, 6), and ponies (7).

Studies have also shown that Bb can persist despite antibiotic
treatment in the following human cells, tissues, organs, and body
fluids:

* Fibroblasts (8; Mark Klempner, an IDSA LD guideline panel member in
2006, is an author of this study)

Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20621802&retmode=ref&cmd=prlinks

Excerpt:

Lyme optic neuritis (ON) is a rare disease and only a few cases
have been reported. We describe two cases of isolated Lyme ON,
one with recurrence 9 months after the appearance of initial
symptoms. Diagnosis criteria for multiple sclerosis and
neuromyelitis optica were not met. The etiological diagnosis was
based on European case definition criteria for neuroborreliosis.
Both patients had positive serum and cerebrospinal fluid
serology, a positive intrathecal anti-Borrelia antibody index,
and a good outcome on ceftriaxone. Specific diagnosis of Lyme ON
is important since improvement of visual acuity is possible with
specific antibiotherapy, even after many months. Copyright (c)
2010 Elsevier B.V. All rights reserved.

Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20464556&retmode=ref&cmd=prlinks

Excerpt:

Lyme disease is a tick-borne spirochetal infection that may
affect the heart.
Cardiac manifestations include conduction disturbances and other
pathologies of the heart. We report on a 37-year old male, who
was admitted to the emergency department because of Cardiac manifestations Physical examination and the initial
laboratory values revealed no abnormalities. The patient’s
electrocardiogram on admission revealed newly diagnosed
bradycardia due to atrioventricular heart block. The ventricular
heart rate was 35/min. The patient was admitted to the ICU. Lyme
serology and Western blot were positive for Borrelia antibodies.
After institution of antibiotic therapy with ceftriaxone,
atrioventricular heart block resolved rapidly. We therefore have
to assume that in this patient Lyme carditis was the cause of
third-degree AV block.

Full article: http://informahealthcare.com/doi/abs/10 … 1003687294

Excerpt:

A 57-year-old man was referred for a painful acute inferior visual field defect in his right eye.
Fundus examination of the right eye revealed diffuse optic disc oedema compatible with a papillitis. Cerebrospinal fluid (CSF) findings were consistent with lymphocytic meningitis, and serologic tests for Lyme disease were positive in both serum and CSF.
After treatment with ceftriaxone and bolus of methylprednisolone, right eye inferior altitudinal visual field defect persisted despite resolution of papillitis, and fundus examination disclosed a superior optic atrophy in the right eye.
To our knowledge, it is the first reported case of a unilateral Lyme optic neuritis occurring simultaneously to neuroborreliosis and further complicated by non-arteritic anterior ischaemic optic neuropathy

Full article:

http://www.springerlink.com/content/b8x4742136623114/

Excerpt:

Abstract Dilated cardiomyopathy (DCM) represents the third most common cause of heart failure and the most frequent cause of heart transplantation. Infectious, mostly viral, and autoimmune mechanisms, together with genetic abnormalities, have been reported as three major causes of DCM. We hypothesized that Lyme disease (LD), caused by spirochete Borrelia burgdorferi (Bb), might be an important cause of new-onset unexplained DCM in patients living in a highly endemic area for LD such as the Czech Republic.

Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine,
University of California at Davis, One Shields Avenue, Davis, California 95616;
Division of Infectious Diseases, Department of Medicine, State University of New
York at Stony Brook, Stony Brook, New York 11794. Continued