All Posts Tagged With: "CSF"

Excerpt:

In acute LNB, all
patients had elevated cerebrospinal fluid (CSF) leukocyte counts. In
contrast to infections by other bacteria, CSF lactate was lower than 3.5
mmol/l in all but 5 patients. The CSF findings did not differ between
polyradiculoneuritis, facial palsy, and meningitis. The CSF in LNB
patients strongly differed from CSF in VM patients with respect to
protein concentration and the CSF/serum albumin quotient.

Full article: http://www.ncbi.nlm.nih.gov/pubmed/2795099

Excerpt:

In 1987, follow-up studies were conducted on 72 patients who had had meningoradiculitis and encephalomyelitis (8 patients) due to Borrelia burgdorferi 5-27 years previously. These patients had not been treated with antibiotics, either during the acute disease or during the interval prior to follow-up studies. The patients had exhibited the typical symptoms of Bannwarth’s syndrome during the acute phase. At the follow-up studies, 33 patients showed no, and 23 only mild, clinical residual symptoms including normal CSF findings and low-positive serum IgG borrelia antibody titres (IFT; ELISA). Three patients without sequelae exhibited persistent intrathecal secretion of oligoclonal B. burgdorferi-specific CSF IgG antibodies (Immunoblot; positive borrelia CSF IgG antibody titres). Thirteen patients exhibited mild-to-medium sequelae with persistent intrathecal formation of oligoclonal B. burgdorferi-specific CSF IgG antibodies, up to 21 years after the acute illness. This persistence can be interpreted as an “immunological scar syndrome”. Our follow-up studies appear to indicate that neurological manifestations of B. burgdorferi infections are generally (with few exceptions) of a benign nature. Most patients can be classified as having been cured without antibiotic therapy. No late manifestations of chronic progressive CNS borreliosis comparable to that of neurosyphilis have been seen following acute untreated neuroborreliosis.

Full article: https://www.thieme-connect.com/ejournals/abstract/neuropediatrics/doi/10.1055/s-2004-819478

Excerpt:

Case report: A 6-week-old girl developed fever, irritability, meningeal signs with bulging fontanelle and a partial, secondary-generalized seizure. CSF yielded pleocytosis (172 lymphocytes, 81 mono-cytes/ul) and elevated protein (0,83g/l), cranial MRI showed encephalitic signs in both frontal and parietal lobes. Because of a tick bite in an endemic area 10 days before admission, ELISA-IgG and IgM to TBE-virus were sought and found in serum, whereas Borrelia burgdorferi serology, Herpes-simplex virus PCR and bacterial CSF-culture were negative. Phenobarbitone was administered because of repetitive seizures, while the EEG showed series of sharp waves in the right parieto-temporal region. She consecutively became seizure free. At first follow-up after 6 weeks she demonstrated pathologic neurological signs with increased muscular tone, hyperreflexia, fidgety movements, and EEG showed slow waves in the right parieto-temporal region.

Full article: https://www.thieme-connect.com/ejournals/abstract/neuropediatrics/doi/10.1055/s-2006-974121

Excerpt:

Neuroborreliosis often presents with cranial nerve palsy, aseptic meningitis or meningoencephalitis. Cerebral arteriopathy has rarely been reported as single cases. Here we present a retrospective analysis from 1997 to 2005 in the Berlin area. In this period neuroborreliosis was confirmed in 47 children through the finding of specific antibodies against Borrelia burgdorferi in CSF.

22 (47%) suffered from facial palsy as a presenting symptome, in one of them the palsy was bilateral. Four children (9%) had palsies of other cranial nerves, and four patients (9%) presented with paresis of an arm, hemiparesis, or spastic paraparesis. 16 children (34%) reported headache on admission, 15 (32%) presented with myalgia and/or arthralgia. Two patients (4%) had paraesthesia, another two (4%) were atactic. Ten (21%) had unspecific symptoms such as fever, fatigue, loss of appetite, or nausea. Other symptoms included general slowdown, sensoric or motoric aphasia, agitation, confusion, incomplete Horner’s syndrome, and mucosa haemorrhage, each in one patient.

In 19 patients (40%) cerebral imaging was performed. 13 (68%) were found to be normal, or rather revealed typical lesions in a patient with an underlying neurofribromatosis type 1. In one child with hemiparesis, and in one with multiple cranial nerve palsies, arterial subtraction angiography (DAS) confirmed multifocal vasculitis and dissection of the left Aa. vertebralis and basilaris, respectively. In one girl with hemiplegia, MRI revealed an infarction of the according internal capsule. Although angiography was not done this finding is suspicious of focal arteriopathy. The girl also had a homozygous mutation of factor V Leiden.