All Posts Tagged With: "Genetics"

Linda’s Comments: This destroys the “expert” standing of so many autism so-called experts so do not expect overnight acceptance of the environment causation, which to anyone not involved in genetic research will find is clearly the logical explanation for not just autism but the fact that in USA one in four in school today are on drug therapy for some condition, diebetes, asthma, mental issues including depression adhd, obsessive compulsive and so on. 

Dr. Gordon’s Comments:

This is a bombshell! Autism genetic causation with millions of dollars invested in this wrong direction is all but dead when the world reads the attached in-depth report.

Of course, erroneous ideas hang around in medicine for years, as there is so much money involved in sticking with out-moded concepts. This destroys the “expert” standing of so many autism so-called experts so do not expect overnight acceptance of the environment causation, which to anyone not involved in genetic research will find is clearly the logical explanation for not just autism but the fact that in USA one in four in school today are on drug therapy for some condition, diebetes, asthma, mental issues including depression adhd, obsessive compulsive and so on. 

This latest large study moves the pendulum away from genetic causation back to environment!! This study is carefully reported here in all detail so if you are involved in autism please read the attached in its entirety, as there are important details you will want to express accurately if you are advising patients or teaching.

I have always known that what Andrew Wakefield reported on, see his website and book Callous Disregard, had merit (IE MMR triggered autism in what had seemed to be normal children up until then). I have dealt with many of these families and attended numerous conferences

However, things are not always simple A + B = C and Thiomersal may not be acting alone and there are these Epigenetic issues we know are happening when substances like Bisphenol A impair methylation, as Randy Jirtle at Duke has documented in Agouti mice. Then the issue becomes one of what are the contributing environmental toxins and they may well vary from case to case. Then when you try to study which nutrient deficiencies are contributing to the autism spectrum, you have issue including D, Magnesium etc and now issues around the need for methylation support in order to better handle the load of toxins found in every child’s cord blood (see Ten Americans at www.ewg.org). 

Then the bomb shell of cerebral folate deficiency now reported in NEJM last week where we find that some antigen is blocking the folate receptors in brain and the only hint of nutrient deficiency was documented only in cerebral spinal fluid. Now we have many potential culprits for this new autoimmune disease of the folate receptor – milk protein or whatever you want to implicate to help explain why the folate receptor in brain are blocked and cannot take up folic acid unless in the form of Folinic acid or 5’MTHF and apparently needed by some in significant orthomolecular levels.

Now we have the time line of events and a turning point in the disease was 1988, which we now find is when vaccine manufacturers turned away from egg and incorporated aborted fetal tissue for vaccine production. 

WILL someone ever make sense of all this so that we can stop this epidemic? 

I vote for anyone wanting a healthy baby to start a one or two year aggressive detox program for prospective mom and dad along the lines I advocate with oral chelation including my Power Drink with ZeoGold added along with regular exercise and some sauna exposure to enhance sweating, as a minimum.

Then hopefully start a boycott of all vaccines made on aborted fetal tissue that includes 24 of them today. That would be nice but since that in some countries is met with jail terms and a gun pointed at the prospective recipient of the vaccine, maybe we have to settle for now with trying to decrease the number of adverse outcomes by at minimum using aggressive Vitamin C based oral program. That means using a minimum of one gram per 10# of weight or roughly for year of age, as one program to try to diminish the clear risk I see in associated with current vaccine use in a world population whose immune system is compromised from birth with over 220 known toxins including an average of over 1000 times more lead in tissues than was present 700 years ago (see Cal Tech, Clair Patterson). 

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Link: http://www.ageofautism.com/2011/07/new-autism-twin-study-demolishes-decades-long-belief-in-genetic-causation.html

Excerpt:

For over two decades now, so-called “autism experts” have been claiming that autism is more than 90% caused by genes. The influence of these claims on autism policy and research funding is hard to overstate. But few realize that the basis of these claims hangs on a fragile evidence base: two small twin studies–one from Great Britain, the other from Scandinavia–that reported high rates of concordance for autism among identical twins and no concordance at all among fraternal twins. Last week, the largest and most rigorous twin study ever conducted, the California Autism Twin Study (CATS) reported contradictory new evidence that struck a devastating blow to these claims. The CATS identical twins had lower and the fraternal twins higher concordance rates than past studies, a striking finding that suggests that instead of being highly heritable, the vast majority of autism cases stem from environmental causes.

Linda’s comments:  Unfortunately XMRV is “real”….

Dr. Gordon’s Comments: Many still hope that XMRV is just a bad dream. Read this and you may conclude that it is real. It makes my F.I.G.H.T. program all the more prescient, as it is based on reality.  There is always some chronically increased body burden of pathogen is almost every chronic disease.

Of course we cannot afford medical care that treats those causes but at least it is nice to learn what the truth is and why so many people are chronically ill today.  Infection is one part of the puzzle and yet 99% of all patients cannot even get a test for lead or mercury levels to say nothing of even considering one or more chronic infections when they present with all this fatigue. Antidepressants get the patient out of the office in the allotted 10 minutes or less. 

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com                 

Link: http://tiny.cc/2oibh

Excerpt:

American Red Cross Statement on XMRV and Chronic Fatigue Syndrome
National Headquarters
2025 E Street, N.W.
Washington, DC 20006
www.redcross.org 
Contact: Public Affairs Desk

WASHINGTON, Friday, December 03, 2010 — At present, there are no specific federal recommendations regarding deferral of individuals with Chronic Fatigue Syndrome (CFS) or other diseases that have been associated with Murine Leukemia Virus-related virus (XMRV) infection. Nevertheless, in the interest of patient and donor safety, the American Red Cross will defer indefinitely any donor who reveals during the donor interview that they have been diagnosed with CFS.

XMRV infection has been associated in some studies with prostate cancer and chronic fatigue syndrome, but at the present time these disease associations have yet to be confirmed.

There is currently insufficient data to conclude that XMRV is transmitted through blood transfusion. However, the National Heart, Lung and Blood Institute (NHLBI) Task force is conducting research to determine the frequency of the virus in the donor population, whether it is transfusion-transmitted, and whether recipients become infected and develop the disease.

Genetics also influences our ability to withstand the chemicals we are exposed to, as in this research on Parkinson’s disease. Remember some can eat fish and the mercury they consume clears in as little as 40 days whereas others take nearly 6 months to clear the same dose of mercury.

We have proof from Harvard that the lower level of lead in bones reduces dramatically the incidence of death from heart disease (i.e. high levels have 6 times the death rate) so this is a life time challenge we all face now that we have polluted our earth.

From the aDepartment of Epidemiology, UCLA School of Public Health, Los Angeles, CA; bDepartment of Environmental Health Sciences, School of Public Health, UC Berkeley, CA; cDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA; dDepartment of Neurology, UCLA School of Medicine, Los Angeles, CA; and eDepartment of Environmental Health Sciences, Center for Occupational and Environmental Health (COEH), UCLA School of Public Health, Los Angeles, CA.

BACKGROUND:: Human, animal and cell models support a role for pesticides in the etiology of Parkinson disease. Susceptibility to pesticides may be modified by genetic variants of xenobiotic enzymes, such as paraoxonase, that play a role in metabolizing some organophosphates. 

METHODS:: We examined associations between Parkinson disease and the organophosphates diazinon, chlorpyrifos, and parathion, and the influence of a functional polymorphism at position 55 in the coding region of the PON1 gene (PON1-55). From 1 January 2001 through 1 January 2008, we recruited 351 incident cases and 363 controls from 3 rural California counties in a population-based case-control study. Participants provided a DNA sample, and residential exposure to organophosphates was determined from pesticide usage reports and a geographic information system (GIS) approach. We assessed the main effects of both genes and pesticides in unconditional logistic regression analyses, and evaluated the effect of carrying a PON1-55 MM variant on estimates of effects for diazinon, chlorpyrifos, and parathion exposures. 

RESULTS:: Carriers of the variant MM PON1-55 genotype exposed to organophosphates exhibited a greater than 2-fold increase in Parkinson disease risk compared with persons who had the wildtype or heterozygous genotype and no exposure (for diazinon, odds ratio = 2.2 [95% confidence interval = 1.1-4.5]; for chlorpyrifos, 2.6 [1.3-5.4]). The effect estimate for chlorpyrifos, was more pronounced in younger-onset cases and controls (</=60 years) (5.3 [1.7-16]). No increase in risk was noted for parathion. 

CONCLUSION:: The increase in risk we observed among PON1-55 variant carriers for specific organophosphates metabolized by PON1 underscores the importance of considering susceptibility factors when studying environmental exposures in Parkinson disease.

This issue about flame retardant is the tip of the iceberg. Go to Google and search on Ten Americans and find a video to learn what else is in everyone and at a much higher concentration in every newborn. Join me as I try to detox the world using things like Zeolite, high dose oral Vitamin C, Beyond Fiber, Greens, Maca and daily Zeolite starting with ACZ and then move on to ZeoGold, at least one daily for life.

Go to www.gordonresearch.com and watch my webinars on FIGHT and then the hour long specials on FIGHT including Food, Infection, Genetics, Hormones and Heavy Metals and Toxins. I find most health problems are multifactorial and the acronym FIGHT helps remind my friends and patients to leave no stone unturned in their quest for optimal health, as I clearly am enjoying now at last at age 75. Detoxing is a life time program!!

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Full article: http://articles.mercola.com/sites/articles/archive/2010/07/06/flame-retardant-causes-altered-thyroid-hormone-levels.aspx

Excerpt:

Pregnant women with higher blood levels of PBDEs, a common class of flame retardants, had altered thyroid hormone levels — a fact that could have implications for fetal health. 
PBDEs, or polybrominated diphenyl ethers, are organobromine compounds which are found in household items such as carpets, electronics and plastics. PBDEs can leach out into the environment and accumulate in human fat cells. 

Eurekalert reports:
“Studies suggest that PBDEs can be found in the blood of up to 97 percent of U.S. residents, and at levels 20 times higher than those of people in Europe. Because of California’s flammability laws, residents in this state have some of the highest exposures to PBDEs in the world.”
Sources:
   Eurekalert June 21, 2010 
   Environmental Health Perspectives June 21, 2010

Are you sick and tired?  My FIGHT4YOURHEALTH program can change your life even if you think LYME is your only problem. Learn more and become vibrantly healthy again.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Full article: http://bolenreport.com/feature_articles/feature_article072.htm

Excerpt:

Most people battling chronic Lyme disease think of the illness as an infection caused by a bacterium known commonly as Borrelia Burgdorferi, generally transmitted via the bite of an infected tick.  What many don’t recognize, however, is that recovery from chronic Lyme disease requires a recognition that the disease is truly a much more complex illness.  Recovery often challenges one to consider more than just infection as the single causative agent involved in the disease process.  It is through looking beyond the infectious component of Lyme disease and understanding the equally important aspects of damaging heavy metals and other toxic insults that a more full and lasting recovery may be realized.

Garry F. Gordon MD, DO, MD (H) co-founded the American College for Advancement in Medicine (ACAM) and serves as the President of Gordon Research Institute.  Dr. Gordon graciously spent a couple of hours with me sharing his views on chronic Lyme disease and those factors that are important in recovering from chronic illness. 

Dr. Gordon acknowledges Lyme disease as a serious infection which can lead to a wide-variety of health challenges.  He does not, however, hyperfocus on the specific tick-borne pathogens which cause the disease.  He instead believes that a multitude of infections are prevalent in anyone with chronic ill health.  In addition to these numerous infections, our state of health is closely tied to our total body burden of endogenous and exogenous toxins.  When looking at why illness is present, it is important to look at a number of factors including genetics, chronic infections, and total body burden of heavy metals and other toxins.

Peering into one’s genetic makeup can be quite helpful when establishing the proper course of action and considering what factors may have contributed to one’s state of health.  The more precisely a practitioner can understand the genetic contributors, the more accurately a treatment protocol can be outlined to fit a person’s unique needs.  As an example, a specific gene mutation can suggest an inability of the body to remove toxic heavy metals.  Thus, even tests performed to determine whether or not one is heavy metal toxic can be incorrect if the metals are not being released due to this specific genetic profile.  Where many doctors may miss a heavy metal toxicity issue in these patients, a practitioner incorporating a genetic review into their diagnostic workup is much better equipped to evaluate the potential impact of toxic metals on the overall state of health.

Imaging Technique Leads to Better Understanding

ScienceDaily (Nov. 16, 2009) — Using a powerful microscopic live imaging technique, a research team led by Dr. Justin Radolf, professor in the Departments of Medicine and Genetics and Developmental Biology at the University of Connecticut Health Center, has discovered the way ticks transmit Lyme disease to humans is different than previously thought. The research is published online in the Journal of Clinical Investigation. Continued

This is an EXCELLENT newsletter to subscribe to.  Also the two (2) books listed
below by Mark Sircus Ac., OMD  are also first class.  Well worth the money, IMHO.

Regards,
Linda

… from IMVA Medical News Commentaries list.

Yulia Tymoshenko, prime minister of Ukraine and a candidate in upcoming
national elections, visits a children’s hospital in western Ukraine.

Prime Minister Tymoshenko stated, “We cannot relax even for a moment because the World Health Organization (WHO) predicts two more waves of flu, including the bird flu, are expected in Ukraine. There is no alternative to vaccination. The entire world is going this way…” A day earlier she admitted she was not vaccinated and that she prefers “like all other people” plans to rely on garlic, onion and lemon as a way of preventing the flu. Commenting on what’s going on in Eastern Europe F. William Engdahl says, “The degree of fraud, deceit, official cover-up and outright criminal endangerment of the broad population by the current Swine Flu hysteria is seemingly without precedent.” Continued