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Ehrlichiosis, a tickborne illness transmitted by tick vectors Amblyomma
americanum and Ixodes scapularis, can be acquired in endemic areas. Clinical
manifestations range from asymptomatic to fulminant in nature. We report three
cases of ehrlichiosis in pediatric oncology patients, one of whom was a stem
cell transplant recipient. Early symptoms included fever, malaise, and vague
gastrointestinal symptoms. Laboratory abnormalities were initially attributed to
chemotherapy toxicity. Illness was severe in all three patients and one patient
died even after initiation of doxycycline.

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The study “provides preliminary evidence that milk thistle may be a safe, effective, supportive-care agent,” the researchers concluded in an online report in Cancer.

“Milk thistle needs to be studied further, to see how effective it is for a longer course of treatment, and whether it works well in reducing liver inflammation in other types of cancers and with other types of chemotherapy,” Kelly said in a press release issued by the American Cancer Society, publisher of Cancer. “However, our results are promising as there are no substitute medications for treating liver toxicity.”