Lipoic acid – F.I.G.H.T for your health!

Vitamin deficiency and age-related disorders

Linda — Tue, 14 Sep 2010 04:58:28 +0000

Triage theory by world famous Bruce Ames explains why I am getting younger by the year. This world-class biochemist has provided the scientific documentation that we all have some small inborn errors of metabolism so we are not operating at our peak if we settle for RDA level of nutrients. His earlier work has provided the scientific framework validating my years of work in Orthomolecular Medicine. Now he has taken his tremendous knowledge of nutrition and has seen how this ties into mitochondrial diseases and aging.

This is the tip of the iceberg. You need to search on Bruce Ames and his close associate Les Packer PhD who have also explained how and why we need CoQ and Carnitine and the all R form of Lipoic acid if it is fully stabilized, to see age reversal in old rats. See his full page ad in every issue of Scientific America and learn more about why I do not just have rich urine when I take my multiple supplements each day. See my personal nutrition program on my website.

For many Professor Ames needs no introduction. In the 1970s, he invented the Ames test, a simple and inexpensive assay to check the mutagenicity of compounds. Since then he has dedicated his research to understanding the biochemistry of aging with a focus on mitochondria, the power plants of our cells, as well as how micronutrients may prevent disease, malnutrition, and obesity.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Full article: http://www.nutraingredients.com/Product-Categories/Minerals/Bruce-Ames-Vitamin-insufficiency-boosting-age-related-diseases/?utm_source=Newsletter_Product&utm_medium=email&utm_campaign=Newsletter%2BProduct

Excerpt:

It is literally all about living for today. By understanding that nature favours survival today over tomorrow, a theory that vitamin inadequacy is behind the rise in chronic diseases “makes sense… and it is almost certainly going to be right,” says world-renowned scientist Bruce Ames.

In an exclusive interview with Stephen Daniells, Professor Bruce Ames from the University of California, Berkeley explains why his “triage theory” could have enormous implications for human health.

For many, Professor Ames needs no introduction. In the 1970s, he invented the Ames Test, a simple and inexpensive assay to check the mutagenicity of compounds. Since then he has dedicated his research to understanding the biochemistry of ageing, with a focus on mitochondria, the power plants of our cells, as well as how micronutrients may prevent disease, malnutrition, and obesity.

So, when the native New Yorker with over 450 scientific publications tells you his triage theory is “the most important thing I have ever worked on”, you sit up and listen.

Evolutionary mechanisms
Triage – from the French word trier meaning to sort, separate, or select – works on the battlefield by military doctors prioritising treatments depending on the probable survival of the wounded.

Prof Ames’ theory works in much the same way: By appreciating that natural selection favours short-term survival over the long-term, Prof Ames’ hypothesised that our short-term survival is achieved by prioritising the allocation of scarce micronutrients. In other words, to stop us falling over from a lack of iron in the heart, for example, iron is pulled from non-essential sources.

Plasma Pharmacokinetics of R-(+)-Lipoic Acid – Dr. Gordon & Linda comment

Linda — Thu, 09 Sep 2010 16:11:37 +0000

Linda’s comment: Zeo Gold ROCKS….I have been taking Zeo Gold fromwww.longevityplus.com since it came out….I started with the ACZnano Zeolite, which binds in the body so it doesn’t bounce back, then I graduated to the Zeo Gold, but still take 5 sprays 4-5 times daily of the ACZnano Zeolite….This product is everything that Dr Gordon says it is….I won’t be without it…Both of these are part of the FIGHT protocol and I have been dissolving biofilms using the FIGHT protocol….

Zeo Gold works on everyone due to the SYNERGY of its world class ingredients. There are extensive research papers on each ingredient that stand alone as proven effective so taken all together you may feel years younger in a few weeks.

YOU will want to work to higher doses slowly to increase the effects you feel; toxins took years to accumulate and this just gets better and better. You will be getting rid of toxins and the fecal changes alone will amaze you at higher doses, as the Biofilm is changed.

How is ZEO GOLD changing lives? It has set a new standard for effective lifetime detoxification that you feel, and can see, and document increased exercise tolerance, memory, aches and pains gone. There is nothing that does not improve from sexual energy to sleep patterns, as you really lower all toxins in your body, not just lead.

The synergy from the five proven ingredients is just part of the story; each ingredient is also the best in its class! The exciting feedback from users of Zeo Gold tells us that this product is a home run.

The active ingredients in Zeo Gold include the most advanced form of Lipoic acid available anywhere. Zeo Gold contains an advanced form of Lipoic acid shown to absorb 21 times better. When you understand the proven benefits of Lipoic acid you will not go a day without taking the best. I am sure that you are not getting this form of Lipoic acid now. This form changes everything. (Alpha Free, Synthetic Free).

The University of Pennsylvania has proven that some forms of oral Glutathione are effective, not a waste as many continue to mistakenly believe.

The Humic Acid in ZeoGold is premium Grade which has been the subject of extensive scientific research and has been shown to aid the body’s ability to maintain overall health. The Zeolite sets new standards for efficacy, as it provides at least 10 times the surface area of any other zeolite for human consumption available anywhere.

The Ascorbic Acid is the world‘s leading Vitamin C product, BioEn’R-G’y C with METHYLATION factors (MSM, TMG) and more.

If you are not treating yourself and your family with this product, you are wasting valuable time as it takes time to increase the dose since there are real changes in your stool frequency for the first two plus months as toxins leave.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Excerpt:

Research Abstract
BACKGROUND: The racemic mixture, RS-(+/-)-alpha-lipoic acid (rac-LA) has been utilized clinically and in a variety of disease models. Rac-LA and the natural form, R-lipoic acid (RLA), are widely available as nutritional supplements, marketed as antioxidants. Rac-LA sodium salt (NaLA) or rac-LA potassium salt (KLA) has been used to improve the aqueous solubility of LA.

STUDY RATIONALE: Several in vitro and animal models of aging and age-related diseases have demonstrated efficacy for the oral solutions of LA salts in normalizing age-related changes to those of young animals. Other models and studies have demonstrated the superiority of RLA, the naturally occurring isomer over rac-LA. Despite this, RLA pharmacokinetics (PK) is not fully characterized in humans, and it is unknown whether the concentrations utilized in animal models can be achieved in vivo. Due to its tendency to polymerize, RLA is relatively unstable and suffers poor aqueous solubility, leading to poor absorption and low bioavailability. A preliminary study demonstrated the stability and bioavailability were improved by converting RLA to its sodium salt (NaRLA) and pre-dissolving it in water. The current study extends earlier findings from this laboratory and presents PK data for the 600-mg oral dosing of 12 healthy adult subjects given NaRLA. In addition, the effect of three consecutive doses was tested on a single subject relative to a one-time dosing in the same subject to determine whether plasma maximum concentration (Cmax) and the area under the plasma concentration versus time curve (AUC) values were comparable to those in animal studies and those achievable via intravenous infusions in humans.

METHODS: Plasma RLA was separated from protein by a modification of a published method. Standard curves were generated from spiking known concentrations of RLA dissolved in ethanol and diluted in a phosphate-buffered saline (PBS) into each individual’s baseline plasma to account for inter-individual differences in protein binding and to prevent denaturing of plasma proteins. Plasma RLA content was determined by the percent recovery using high-performance liquid chromatography (electrochemical/coulometric detection) (HPLC/ECD).

RESULTS: As anticipated from the preliminary study, NaRLA is less prone to polymerization, completely soluble in water, and displays significantly higher Cmax and AUC values and decreased time to maximum concentration (Tmax) and T1/2 values than RLA or rac-LA. In order to significantly extend Cmax and AUC, it is possible to administer three 600-mg RLA doses (as NaRLA) at 15-minute intervals to achieve plasma concentrations similar to those from a slow (20-minute) infusion of LA. This is the first study to report negligible unbound RLA even at the highest achievable plasma concentrations.
(Altern Med Rev 2007;12(4):343-351)

Lipoic Acid: New Research & the New Paradigm

Linda — Fri, 12 Feb 2010 00:15:33 +0000

Linda’s comments: ZeoGold is a very important part of the FIGHT program. I take it daily. In fact during the testing period I took as much as one teaspoon of ZeoGold daily. I take this with one teaspoon=4000mg of the BioEnergyC. I also take three additional teaspoons of BioEnergy C throughout the day. I again urge each and everyone of you to study the FIGHT program. I have been on the FIGHT program 1 1/2 years now, with GREAT results. Even though I’m taking the ZeoGold, I continue to take 5 sprays, 3x’s daily and sometimes more of the ACZnano Zeolite.

Lipoic acid is the most exciting supplement available today and it is available from Longevity Plus in ZeoGold. Please note the following comments from the attached. It is helping lower blood pressure and lowering glucose while helping chelate out toxins and repairing the liver!

“In fact, to our knowledge there are few compounds as multifaceted as Lipoic acid as a bioactive agent. It is an inducer of cellular signaling pathways, insulin mimetic, a hypotriglyceridemic agent, a vasorelaxant/anti-hypertensive compound, a metal chelator and an adjuvant for neurocognitive function. Thus, it will be important to define the precise cause-and-effect relationship between Lipoic acid and its cellular targets of immediate action. 4””

No other Zeolite has this function.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

http://www.geronova.com/content/lipoic-acid-new-research-new-paradigm

Lipoic Acid: New Research & the New Paradigm
Submitted by David Carlson on Mon, 08/17/2009 – 23:11

One of the things I love about my job is that I get to read and study and think a lot about lipoic acid. In fact, I try to relate almost every new chemistry, biochemistry or molecular biology paper back to how it relates to lipoic acid which leads to frequent accusations that Im a one dimensional lipoic acid geek. I prefer to think of it as being focused as I have also realized I am an inefficient multi-tasker. Undeterred by these (sometimes) playful jabs, I get to spend time digging through the dusty old archives searching for gems of information as well as reviewing and digesting the hot off the press and even ahead of press articles.

Over the years Ive learned that time spent in the library can be as or more productive than time spent in the lab. Im currently attempting to post new info as soon as I find it and it is particularly rewarding when I find new papers supporting my theories. Until recently I never imagined joining the blogosphere until I realized it is much faster to blog the findings and theories than to design and run the experiments to prove them and to get the findings published. Sometimes it takes several years to get from a concept or hypothesis to a completed experiment and publication. Im in touch with many lipoic acid researchers around the world but they frequently have their own agenda which is driven partially by interest but mostly by funding opportunities. Academics spend a significant of time vying for limited government funding.

Ive been working for the last couple of years compiling all the lipoic acid stereochemistry research I could find.1 I have been writing a comprehensive review article to advance my insights & ideas concerning the mechanisms of action of lipoic acid and specifically the role of stereochemistry which needs to be completed and submitted this year.2

Some of what I had to say has been recently said. Last year, Hagens group at LPI published a paper supporting their (and my) theories that lipoic acid is not really an in vivo antioxidant in the classical sense but is a stressor that induces cellular protective mechanisms.3

Yesterday, I got a Pub Med alert to the ahead of press review by the same group.4 The article is excellent and fairly comprehensive and at least raises the question of the role of stereochemistry in the mechanisms of action which was neglected in previous reviews 9,10 but doesnt go far enough to show the evidence to date indicates R-lipoic acid is superior in most cases to racemic alpha lipoic acid or S-lipoic acid. Please see my 1st blog, R-lipoic acid is the Eutomer of LA.11

So I have new motivation to finish and to publish my paper despite the up to date and comprehensive nature of the review article by Torys group. Shay et al advance many of the ideas and theories that Ive been developing over the years and introduced in an on-line publication5 and discussed in more detail in my OCC presentation.2

Anthony Smith, Tory Hagen and David Carslon – OCC Conference, 2008.

To be fair and honest, although I realized long ago that lipoic acid was much more than an antioxidant and despite its categorization as such most likely does not exert its in vivo benefits as a scavenger of ROS, RNS, RSS7 and may in fact act via pro-oxidant mechanisms, it is difficult to know to what extent my ideas were influenced through countless hours of discussion with Dr Anthony Smith; one of our scientific advisors while he was working with us on our early lipoic acid pharmacokinetic studies.8 Anthony got his doctorate and did post doc work in Hagens lab & is one of the co-authors of the new article and was deeply indoctrinated into this mindset. Hopefully my work had some influence on him and the LPI group as well.

Regardless of where the ideas originated, I am excited that these theories, supported by in vivo dose, concentration and time considerations rather than the heroic and unrealistic concentrations and incubation times used in vitro are finally getting out to a wider audience as it will change the way people think about lipoic acid. It also means that my ideas are being confirmed and validated by one of the worlds most respected lipoic acid research groups. That is always rewarding.

Despite what everyone thinks they know about lipoic acid, it is clear that lipoic acid is not (primarily) an in vivo antioxidant, at least in the sense of a radical scavenger. I am convinced that as this finding becomes more widely known it will direct lipoic acid research into the future and will become much more widely appreciated by the public for its unique characteristics and roles in improving the health span.

According to Shay et al;
In fact, to our knowledge there are few compounds as multifaceted as lipoic acid as a bioactive agent. It is an inducer of cellular signaling pathways, an insulin
mimetic, a hypotriglyceridemic agent, a vasorelaxant/anti-hypertensive compound, a metal chelator and an adjuvant for neurocognitive function. Thus, it will be important to define the precise cause-and-effect relationship between lipoic acid and its cellular targets of immediate action. 4

I should also add that it will be important to find its cellular targets of delayed action since it may induce downstream effects even after it has been metabolically transformed and cleared from the body.

1. http://www.geronova.com/content/research-overview
2. Further characterization of lipoic acid enantiomers provide new research opportunities. Stereochemistry, Pharmacokinetics & Metabolism: Toward a Comprehensive Mechanism of Action. Oxygen Club of California PowerPoint presentation by David A.Carlson, March,15, 2008.
The power point can be downloaded from http://www.geronova.com/content/research-overview
3. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life. 2008 Jun;60(6):362-7. Review.
4. Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Biochim Biophys Acta. 2009 Aug 4.
5. http://www.geronova.com/docs/controlled_release_lipoicacid.pdf
6. http://www.geronova.com/content/anthony-smith-phd
7. Reactive Oxygen Species, Reactive Nitrogen Species & Reactive Sulfur Species
8. http://www.thorne.com/altmedrev/.fulltext/12/4/343.pdf.
9. Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 1997 Sep;29(3):315-31. Review.
10. Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.
Curr Med Chem. 2004 May;11(9):1135-46. Review.
11. http://www.geronova.com/content/r-lipoic-acid-eutomer-lipoic-acid