Link: http://www.lymecommunity.com/forums/ubbthreads.php/ubb/showflat/Number/6207/page/1

Excerpt:

Maryland Medicine Vol. 12; Issue 4
Personal Perspectives on Practicing Medicine Today

My 35th medical school reunion is upcoming. Most of my classmates at Duke Med School are retired. I am still in solo practice in Pocomoke, Maryland far down Route 13 on the Eastern Shore. I have been here since 1980. I see no retirement in sight; there is too much to do.

by Richard A. Van Konynenburg, Ph.D.
9th International IACFS/ME Conference
Reno, Nevada
March 12-15, 2009

Summary

A link has been hypothesized between Lyme disease and chronic
fatigue syndrome (CFS).  This link is based on the Glutathione Depletion-Methylation Cycle Block (GD-MCB)  hypothesis for CFS [6].

The GD-MCB hypothesis proposes that in a person who is genomically predisposed, stressors that place demands on glutathione can cause it to become depleted, and can lead to a partial
block in the methylation cycle. The resulting vicious circle interaction maintains CFS as a chronic condition.

The present paper suggests that Lyme disease is one of the stressors that can produce this
vicious circle interaction in the body of a person who is genomically predisposed. It is suggested that this leads to chronic Lyme disease.

If the Borrelia bacteria are subsequently eliminated by treatment, the patient then has post-Lyme disease syndrome. Post-Lyme disease syndrome is one of the post-infective fatigue syndromes, a category of disorders within chronic fatigue syndrome [25]. A commercial test
panel is available to test this hypothesis [26], and treatment to lift the methylation cycle block and to restore glutathione is available [7] if these are found to be present.