All Posts Tagged With: "Trypanosoma"

Link: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21104602&retmode=ref&cmd=prlinks

Excerpt:

Members of the CURCUMA plant species (Zingiberaceae) have been used for
centuries in cooking, cosmetics, staining and in traditional medicine as
“omnipotent” remedies. Herbal preparations made with, and molecules
extracted from, CURCUMA have been shown to possess a wide variety of
pharmacological properties against malignant proliferation, hormonal
disorders, inflammation, and parasitosis among other conditions. This review
evaluates CURCUMA and its associated bioactive compounds, particularly
focusing on studies examining the parasiticidal activity of these components
against the tropical parasites PLASMODIUM, LEISHMANIA, TRYPANOSOMA,
SCHISTOSOMA and more generally against other cosmopolitan parasites
(nematodes, BABESIA, CANDIDA, GIARDIA, COCCIDIA and SARCOPTES). (c) Georg
Thieme Verlag KG Stuttgart . 
New York. 

Excerpt:

Abstract – Neuropathogenic protozoa have evolved strategies to
breach the blood-brain barrier and invade the central nervous
system. These include transcellular, paracellular and the Trojan
horse routes but the associated molecular mechanisms remain
incompletely understood. Here, we summarize the current
understanding of protozoa penetration across the blood-brain
barrier, focusing on Plasmodium, Babesia, Trypanosoma,
Toxoplasma, Acanthamoeba and Balamuthia. Advances in
understanding the molecular pathways will offer opportunities for
the rational development of novel therapeutic interventions.