All Posts Tagged With: "Lyme neuroborreliosis"

Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20505978&retmode=ref&cmd=prlinks

Excerpt:

INTRODUCTION: Acute transverse myelitis (ATM) is a rare disorder
(1-8 new cases per million of population per year), with 20% of
all cases occurring in patients younger than 18 years of age.
Diagnosis requires clinical symptoms and evidence of inflammation
within the spinal cord (cerebrospinal fluid and/or magnetic
resonance imaging). ATM due to neuroborreliosis typically
presents with impressive clinical manifestations.
CASE PRESENTATION: Here we present a case of Lyme
neuroborreliosis-associated ATM with severe MRI and CSF findings,
but surprisingly few clinical manifestations and late conversion
of the immunoglobulin G CSF/blood index of Borrelia burgdorferi
sensu lato.
CONCLUSION:
Clinical symptoms and signs of neuroborrelial ATM may be minimal,
even in cases with severe involvement of the spine, as shown by
imaging studies. The CSF/blood index can be negative in the early
stages and does not exclude Lyme neuroborreliosis; if there is
strong clinical suspicion of Lyme neuroborreliosis, appropriate
treatment should be started and the CSF/blood index repeated to
confirm the diagnosis.

Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20455197&retmode=ref&cmd=prlinks

Excerpt:

BACKGROUND: Lyme neuroborreliosis (LNB) is the second most common
manifestation of Borrelia burgdorferi sensu lato (s. l.)
infection in Europe. LNB is difficult to differentiate from other
aetiologies of aseptic meningitis. Diagnostic criteria for LNB in
children are not established. Therfore, based on the epidemiology
of LNB in children from Tyrol, the aim of our study was to point
out the necessity of a clear definition of pediatric LNB to avoid
underdiagnosis and overtreatment. PATIENTS AND METHODS: All
medical charts of patients presented with acute peripheral facial
palsy from January 2002 to December 2005 were reviewed. The
patients were rediagnosed according to the criteria of the German
Society of Neurology (DGN). RESULTS: We identified 66 patients
with peripheral facial palsy. 30 children were handled as B.
burgdorferi s. l.
infection.

Excerpt:

Cliniques Universitaires de Mont-Godinne, Universite Catholique
de Louvain, Departement de Pediatrie, Yvoir, Belgium.
david.tuerlinckx@uclouvain.be

Lyme neuroborreliosis (LNB) represents the second most frequent
manifestation of Lyme disease (LD) in Europe after cutaneous
involvement. In the USA, LNB represents the third most frequent
manifestation of LD after cutaneous involvement and arthritis.
The scope of this article is, in the light of recent
publications, to review the specific manifestations of LNB in
children including predictive models, and to discuss diagnosis
criteria, new diagnostic tools and new therapeutic options.
Differences in disease patterns between the USA and Europe are
also highlighted.

Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20377339&retmode=ref&cmd=prlinks

Inflammation has long been implicated as a contributor to pathogenesis
in many CNS illnesses, including Lyme neuroborreliosis. Borrelia
burgdorferi is the spirochete that causes Lyme disease and it is known
to potently induce the production of inflammatory mediators in a variety
of cells. In experiments where B. burgdorferi was co-cultured in vitro
with primary microglia, we observed robust expression and release of
IL-6 and IL-8, CCL2 (MCP-1), CCL3 (MIP-1?), CCL4 (MIP-1?) and CCL5
(RANTES), but we detected no induction of microglial apoptosis. In
contrast, SH-SY5Y (SY) neuroblastoma cells co-cultured with B.
burgdorferi expressed negligible amounts of inflammatory mediators and
also remained resistant to apoptosis. Continued