Efficacy of antibiotic prophylaxis for the prevention of Lyme infeciton

Excerpt:

Background The clinical value of antibiotic prophylaxis in
preventing Lyme disease remains uncertain, owing to a
meta-analysis lacking sufficient power to demonstrate efficacy
and a more recent trial showing effectiveness but lacking
precision. Our objective was to update our prior meta-analysis on
antibiotic prophylaxis for the prevention of Lyme disease, to
obtain a more precise estimate of treatment effect.
Methods Clinical trials were identified by searching MEDLINE,
Embase, the Cochrane Library and trial registries, and by an
assessment of the bibliographies of retrieved articles and
reviews. Trials were selected if their patients were randomly
allocated to a treatment or placebo group within 72 h following
an Ixodes tick bite and had no clinical evidence of Lyme disease
at enrolment.

Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20382722&retmode=ref&cmd=prlinks