Genetics and infectious disease?
By Linda on Feb 24, 2011 in Infections | comments(0)
Link: http://www.cdc.gov/ncidod/eid
Excerpt:
Bacterial Population Genetics in Infectious Disease addresses a set of issues that are extremely provocative in the current climate in which progress is rapidly changing the microbiological landscape. From this perspective, the volume appears at a key moment because of 2 major challenges that have arisen since the beginning of the genomic era: 1) defining what constitutes a species and how to determine this, and 2) determining the structure of the population of the most common bacterial pathogens.
The book opens with a review of the concepts and methods that make it possible to analyze bacterial populations genetically. This presentation immediately brings to the forefront the question of how to define what constitutes a bacterial species (if there is conceptually even such a thing) and the variable evolutionary nature of bacteria. The differences among complexes within species, species, and clones are shown with clear diagrams useful for teaching. In addition, the text also evaluates the lateral transfer of genes, one of the elements that constitute the bacterial genome repertoire, including its effects on the attempts at classification of bacteria. The evolutionary demography of bacterial populations is then examined. These concepts are essential for comprehending and teaching modern microbiology.
In addition, the text describes techniques for evaluating bacterial diversity, such as the search for single-nucleotide polymorphisms or repeats by using sequences encoding proteins or not. These techniques can play a key part in the identification of the clones.
The second part of the book is specifically relevant to clinical microbiology, particularly to emerging bacterial pathogens. The genetic populations of Bacillus anthracis,Campylobacter spp., Enterococcus spp., Borrelia burdorferi, Neisseria meningitidis,Escherichia coli, Salmonella spp., Staphylococcus spp., and Streptococcus spp. are analyzed. The importance of genomic recombinations in microbial evolution is particularly stressed for Streptococcus spp., Neisseria spp., and E. coli, for which the number of recombinations is considered to be higher than that of the number of changes; this conclusion likely alters our perception of the evolution of bacteria. Lastly, a general hypothesis is proposed for Salmonella spp.: that their antigens are selected by passage through specific phagocytic protists from their animal hosts with which they have cospeciation. This assumption is bold and intriguing.
