T regulatory cell numbers and function in Lyme patients
By Linda on Jun 30, 2010 in Infections | comments(0)
Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20506317&retmode=ref&cmd=prlinks
Excerpt:
RESULTS.: In both patient groups, IFN-gamma+ T(H)1 cells in SF were abundant
and enriched ( approximately 50% of CD4+ T cells). In patients
with antibiotic-refractory arthritis, the median percentages of
FoxP3+ Treg were significantly higher in SF than PB (12% versus
6%) (P<0.01) or in SF in patients with antibiotic-responsive
arthritis (12% versus 5%) (P=0.04). Moreover, in the refractory
group, a higher percentage of Treg in SF correlated with a
shorter duration to resolution of arthritis (r = -0.74, P =
0.006). In contrast, patients with fewer Treg had suboptimal
responses to DMARDs and longer duration of arthritis after
antibiotics, and they often required synovectomies for arthritis
resolution. In each group, Treg in SF dampened B.
burgdorferi-specific proliferative responses, and in 2 patients
with refractory arthritis, Treg were functional in non-specific
suppression assays.
