All Posts Tagged With: "chemokine secretion from monocytes/ macrophages"

Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20828409&retmode=ref&cmd=prlinks

Excerpt:

RESULTS: In patients with Lyme arthritis, B. burgdorferi but not
IFN-gamma induced PBMC to secrete CCL4 and CCL2, and B.
burgdorferi and IFN-gamma each stimulated the production of CXCL9
and CXCL10. However, with the
CD14+ cell fraction, B. burgdorferi alone stimulated the
secretion of CCL4; B.
burgdorferi and IFN-gamma together induced CCL2 secretion, and
IFN-gamma alone stimulated the secretion of CXCL9 and CXCL10. The
percentage of T cells expressing CXCR3 or CCR5 was significantly
greater in SFMC than PBMC, confirming that TH1 effector cells
were recruited to inflamed joints. However, when stimulated with
B. burgdorferi or IFN-gamma, SFMC and PBMC responded similarly.

CONCLUSIONS: B. burgdorferi stimulates PBMC or CD14+
monocytes/macrophages directly to secrete CCL4, but spirochetal
stimulation of other intermediate cells, which are present in
PBMC, is required to induce CD14+ cells to secrete CCL2, CXCL9
and CXCL10. We conclude that B. burgdorferi stimulates
monocytes/macrophages directly and indirectly to guide innate and
adaptive immune responses in patients with Lyme arthritis.