All Posts Tagged With: "Dept. of Pathology"

Full article: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20822349&retmode=ref&cmd=prlinks

Excerpt:

Ehrlichia are tick-borne obligately intracellular bacteria that
cause significant diseases in veterinary natural hosts, including
livestock and companion animals, and are now considered important
zoonotic pathogens in humans. Vaccines are needed for these
veterinary and zoonotic human pathogens, but many obstacles exist
that have impeded their development. These obstacles include
understanding genetic and antigenic variability, influence of the
host on the pathogen phenotype and immunogenicity, identification
of the ehrlichial antigens that stimulate protective immunity and
those that elicit immunopathology, development of animal models
that faithfully reflect the immune responses of the hosts and
understanding molecular host-pathogen interactions involved in
immune evasion or that may be blocked by the host immune
response.
We review the obstacles and progress in addressing barriers
associated with vaccine development to protect livestock,
companion animals and humans against these host defense-evasive
and cell function-manipulative, vector-transmitted pathogens.