All Posts Tagged With: "eherlichia"

Link: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21162040&retmode=ref&cmd=prlinks

Excerpt:

Two children presented with a history of fever and rash. Lab values revealed
pancytopenia, elevated ferritin, coagulopathy, and elevated triglycerides.
Both children quickly developed respiratory distress and hypotension
requiring admission to the ICU. Bone marrow biopsies revealed
hemophagocytosis. Studies for Ehrlichia returned positive. The patients were
started on doxycycline and treated for hemophagocytic lymphohistiocytosis
(HLH). Each made a full recovery.
In both patients, testing for MUNC and perforin genes were found to have no
mutation. These two cases demonstrate the importance of considering
Ehrlichiosis as a possible trigger of HLH. Pediatr Blood Cancer (c) 2010
Wiley-Liss, Inc.