Axonal Damage from Lyme
By Linda on Nov 23, 2011 in Infections | comments(0)
Linda’s comment: Lyme neuroborreliosis (LNB) is the most frequent tick-borne infectious disease of the central nervous system. In acute LNB and the rare **chronic state of infection**, patients can experience cognitive deficits such as attention and memory disturbances.
Continuous exposure to intrathecal B. burgdorferi OspC
led to activation of microglia and axonal damage without demonstrable
cognitive impairment in experimental mice. These results suggest that
long-term intrathecal exposure to OspC resulted in axonal damage that
may underlie the neurologic manifestations in chronic LNB.
