All Posts Tagged With: "parasitemia"

Impact of RTS,S/AS02_A and RTS,S/AS01_B on Genotypes of P. falciparum in Adults Participating in a Malaria Vaccine

Clinical Trial

RTS,S, a candidate vaccine for malaria, is a recombinant protein expressed in yeast containing part of the circumsporozoite protein (CSP) sequence of 3D7 strain of Plasmodium falciparum linked to the hepatitis B surface antigen in a hybrid protein. The RTS,S antigen is formulated with GSK Biologicals’ proprietary Adjuvant Systems AS02_A or AS01_B. A recent trial of the RTS,S/AS02_A and RTS,S/AS01_B vaccines evaluated safety, immunogenicity and impact on the development of parasitemia of the two formulations. Parasite isolates from this study were used to determine the molecular impact of RTS,S/AS02_A and RTS,S/AS01_B on the multiplicity of infection (MOI) and the csp allelic characteristics of subsequent parasitemias. Continued

NEW YORK (Reuters Health) Jul 29 – New research indicates that artemisinin resistance among Plasmodium falciparum isolates is common in western Cambodia and that in vitro testing may give false results.

Findings from another study indicate that inoculation of intact sporozoites can induce protection against malaria challenge. Both studies are reported in The New England Journal of Medicine for July 30. Continued