Food Allergies – with comments from Dr. Gordon
By Linda on Feb 1, 2011 in F.I.G.H.T., Food | comments(0)
Food allergy/sensitivities contribute to most chronic diseases to a greater or lesser extent, as explained by my FIGHT program. This review has some new developments from mainstream medicine that you need to be aware of for managing this huge problem for most patients.
“In this review, we will examine the relationship between food hypersensitivity and oral tolerance and explore novel therapeutic approaches to modulate the food allergic response.”
They are moving into mucosally targeted strategies instead of injections for management of this problem.
Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com
Link: http://www.medscape.com/viewarticle/733146?sssdmh=dm1.659803&src=journalnl
Excerpt:
Purpose of review Recent investigation has resulted in significant advances toward definitive therapeutic options for food allergy. In this review, we will explore novel immunotherapeutic interventions for the active treatment of food allergy.
Recent findings Because the injection route for allergen immunotherapy to foods has been associated with an unacceptable risk of severe anaphylactic reactions, use of mucosally targeted therapeutic strategies is of significant interest for food allergy. Allergen-specific immunotherapeutic approaches such as oral, sublingual, epicutaneous, and peptide immunotherapy have demonstrated efficacy in increasing threshold dose and inducing immunologic changes associated with both desensitization and oral tolerance in animal and human trials. More global immunomodulatory strategies, such as Traditional Chinese Medicine and anti-IgE therapy have been shown to effectively target the allergic response, and clinical trials are ongoing to determine the efficacy and safety in human food allergy.Summary
The advent of therapies that target the mucosal immune response to promote oral tolerance have shown great promise in the treatment of food hypersensitivity. However, there is still significant risk of adverse reactions associated with these therapeutic strategies and further study is needed to carefully advance these therapeutic modalities toward general clinical implementation.Introduction
The development of novel therapeutic modalities targeting the mucosal immune response has shown great promise in providing a definitive therapy for food allergy. Because food allergy is likely a multifactorial disorder with both genetic and environmental influences, development of primary prevention strategies has been frustrating and at times counter-productive, making development of a definitive therapeutic option a high priority. In this review, we will examine the relationship between food hypersensitivity and oral tolerance and explore novel therapeutic approaches to modulate the food allergic response.
