All Posts Tagged With: "enzyme"

A relatively common defect involving Sialic acid –sets the stage for patients to develop autoimmune related illnesses! I continue to discuss my FIGHT program, as the best way to approach any autoimmune related condition.www.gordonresearch.com

Possibly, in the future, with evidence this strong, genetic testing for this variant could lead to patients being advised to go on my FIGHT program before they have the symptoms of one of the over 100 different autoimmune related conditions. The best statistics today indicate that over 40% of us have difficulty with either dairy or gluten. So, before we start seeing auto-antibodies to our tissues, those with this variant might want to eliminate those foods and do the rest of the FIGHT program too.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute

Full article: http://www.ncbi.nlm.nih.gov/sites/entrez/20555325?dopt=Abstract&holding=f1000,f1000m,isrctn

Excerpt:

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity.
Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, Macdonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S.
Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

Abstract
Sialic acid acetylesterase (SIAE) is an enzyme that negatively regulates B lymphocyte antigen receptor signalling and is required for the maintenance of immunological tolerance in mice. Heterozygous loss-of-function germline rare variants and a homozygous defective polymorphic variant of SIAE were identified in 24/923 subjects of European origin with relatively common autoimmune disorders and in 2/648 controls of European origin. All heterozygous loss-of-function SIAE mutations tested were capable of functioning in a dominant negative manner. A homozygous secretion-defective polymorphic variant of SIAE was catalytically active, lacked the ability to function in a dominant negative manner, and was seen in eight autoimmune subjects but in no control subjects. The odds ratio for inheriting defective SIAE alleles was 8.6 in all autoimmune subjects, 8.3 in subjects with rheumatoid arthritis, and 7.9 in subjects with type I diabetes. Functionally defective SIAE rare and polymorphic variants represent a strong genetic link to susceptibility in relatively common human autoimmune disorders.

Linda’s comment….Thank you Dr Mercola for speaking up.  I had and still do have toxic reactions when around Roundup or around an area that has used Roundup.  It is criminal in my opinion that the government has allowed Monsanto to produce this deadly toxin.  Why you ask does our government allow this to happen…..easy answer….FOLLOW THE MONEY….yep, money is more important.
 
There are a few things you can do to neutralize the toxins your body absorbs from these toxins and that is to get on a good detox program/protocol.  I have found that FIGHT is an excellent lifelong daily detox protocol….
 
We are hit by 500 to 600 toxins from our environment on a daily basis….then you have them shoving GMO foods and vaccines at you….Our bodies can’t handle these daily assault’s and therefore it is left up to US, YOU and ME to began a good daily detox programs to help neutralize these toxins that we are being slammed with….
 
BTW, if you want to get rid of weeds there is a simple NON-toxic answer…..I make it up by the gallon….take one gallon of Heinz white vinegar, pour a cup of Morton’s toxic salt in the bottle then add 2 tablespoons of  Dawn dishwashing detergent…shake well and pour or use a squirt bottle on the weed and it will die within a few days….safe, non-toxic and you can pound your chest that you did not contribute to our toxic world….<big smile>
 
Again, I want to thank Dr Mercola for being so out-spoken ….now let us all start speaking up.  We consumers can begin to control this toxic world by STOP BUYING THE TOXIC PRODUCTS…
 
Regards,
Linda
 
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France Finds Monsanto Guilty of Lying
Posted by: Dr. Mercola
November 21 2009 | 36,068 views

France’s highest court has ruled that U.S. agrochemical giant Monsanto had not told the truth about the safety of its best-selling weed-killer, Roundup. The court confirmed an earlier judgment that Monsanto had falsely advertised its herbicide as “biodegradable” and claimed it “left the soil clean.” Roundup is the world’s best-selling herbicide. Continued