All Posts Tagged With: "Martin Pall"

Martin Pall talks on Chronic Disease (with comments from Dr. Gordon)

Martin Pall has made a major contribution to our understanding of many of the CHRONIC degenerative diseases we see today. I like the fact that this provides a molecular based explanation that leads to improved understanding of the need for a total nutritional support program in these diseases, which our colleagues all too often dismiss as psychosomatic.

This link will take you into well written materials by Dr Pall that may add to your ability to move beyond today’s differential diagnosis into a more comprehensive understanding of what is really going wrong when our patients develop fibromyalgia, chronic fatigue, chemical sensitivities, etc.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Link: http://www.thetenthparadigm.org/

Excerpt:

Novel Disease Paradigm Produces Explanations for a Whole Group of Illnesses

A Common Causal (Etiologic) Mechanism for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Multiple Chemical Sensitivity, Fibromyalgia and Post-Traumatic Stress Disorder

Martin L. Pall, Professor Emeritus of Biochemistry and Basic Medical Sciences,
Washington State University and Research Director, The Tenth Paradigm Research Group.

The Tenth Paradigm of Human Disease

The basic proposal that is developed here and is amplified further in my book and in my other web pages, is that the NO/ONOO- cycle explanatory model is the tenth major paradigm of human disease.  There are nine well-accepted paradigms listed below along with the NO/ONOO- cycle:

Major Disease Paradigms

1.   Infectious diseases.

2.   Genetic diseases.

3.   Nutritional deficiency diseases.

4.   Hormone dysfunction diseases.

5.   Allergies.

6.   Autoimmune diseases.

7.   Somatic mutation/selection (cancer).

8.   Ischemic cardiovascular diseases.

9.   Amyloid (including prion) diseases.

10.  NO/ONOO- cycle diseases

Explaining Unexplained Illnesses by Martin Pall, PhD

Linda’s comments:  I attended a lecture by Dr Martin Pall regarding NO/ONOO and found it extremely interesting.  You can google him and get a large number of articles by Dr Pall.  Well worth your reading time.

Excerpt:

We are excited to present information from the forthcoming book by Martin L. Pall, PhD, who shows that all these conditions – and probably many others – involve the same key biochemical response: elevated levels of nitric oxide (NO) and its oxidant product peroxynitrite (ONOO), which initiate a biochemical vicious cycle. Although the mechanisms underlying this ongoing NO/ONOO cycle are well-documented, Dr. Pall presents new information about how this cycle interacts to produce patterns of symptoms. The theory elegantly answers many questions, including: Continued