By Linda on Aug 27, 2010 in F.I.G.H.T., Food, Toxins | comments(0)
Excerpt:
Blood-brain barrier (BBB) disruption occurs during human immunodeficiency virus encephalopathy, but the mechanisms involved are not understood. We studied how acute and ongoing exposure to human immunodeficiency virus 1 envelope gp120 alters BBB structure and permeability. Intravenous Evans blue, given before stereotaxic gp120 injection into the caudate putamen of rats, was rapidly extravasated. Gelatinolytic activity, studied by in situ zymography, was increased after gp120 administration and was localized within cerebralvessel walls. The gp120 increased the expression of matrix metalloproteinases (MMPs) 2 and 9. Laminin and claudin-5, key BBB components and targets of both MMPs, were greatly reduced upon gp120 administration. The gp120 increased lipid peroxidation in the vascular endothelium and in neurons. Prior administration of rSV40 vectors carrying the antioxidant enzymes Cu/Zn superoxide dismutase or glutathione peroxidase protected from gp120-induced BBB damage. N-methyl-D-aspartate receptor activation upregulated pro-MMP-9 and increased MMP-9 gelatinase activity, and memantine, an N-methyl-D-aspartate receptor blocker, mitigated gp120-induced BBB abnormalities. Using intra-caudate putamen SV(gp120) to test the effects of chronic exposure to expressed gp120, we determined that oxidant stress and increased BBB permeability occurred as in acute exposure. These data indicate that both direct administration and cellular expression of gp120 lead to disruption of the BBB by increasing MMPs and reducing vascular tight junction proteins via mechanisms involving reactive oxygen species generation and oxidant injury.
By Linda on Jun 12, 2010 in Toxins | comments(0)
Linda’s comment: This is one of the easiest protocols to follow….I have been on the program for 1 1/2 years now and all I can say is don’t waste one more minute….go to www.gordenresearch.com and click on Webinars…then look for FIGHT….yes it takes some time, but the education and awareness you will gleam is well worth the time you will spend…
FROM DR. GORDON:
There is no escaping Mercury from coal burning power plants so what do we tell patients since we are all being adversely affected. We sound unscientific if we suggest that everyone needs to get the lead and mercury out yet that is the truth. But, we need new ways to monitor the severity and the response, such as markers of oxidative stress.
If we try to tease out the increased risk from a local power plant while distant plants in China are polluting everyone, this research will be as difficult as studies on cigarette smoking have been. We now know that second hand smoke is possibly even more toxic.
So with that in mind, if we pollute everyone on the planet with lead and mercury, it will be very difficult to tease out just how much worse the pollution effect if from your local coal burning power plant since environmental factors working through Epigenetics play such a major part of which illnesses you express from YOUR mercury exposure. From the dramatic responses in Parkinson’s patients treated with mercury removal therapy including OSR from Boyd Haley’s research, we can begin to recognize that Mercury exposures express differently in different people at different ages.
The good news is that stopping the excess exposures by restricting mercury containing fish and removing amalgams all seem to show real benefits. Enhanced removal of heavy metals is possible with long-term use of Zeolite, Fiber, High Dose Ascorbic Acid, OSR, etc. Amazingly enough some children recover full speech and many see their tremors stop.
The issue is we cannot stop breathing and since the air always contains toxic metal particulates, everyone on earth today needs lifetime protection.
The problem is to move away from relying primarily on enhanced post provocative chelation studies on urine and into a more unifying concept that recognizes we must lower our exposures to all OXIDATIVE STRESSORS. Moving in that direction will eliminate the tendency to under treat children who may have a block in their ability to excrete heavy metals or have excessive inflammation that is holding the metals in involved tissues despite the use of otherwise normally useful detoxing methods.
Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com
Excerpt:
SAN ANTONIO (April 24, 2008)—How do mercury emissions affect pregnant mothers, the unborn and toddlers? Do the level of emissions impact autism rates? Does it matter whether a mercury-emitting source is 10 miles away from families versus 20 miles? Is the risk of autism greater for children who live closer to the pollution source?
A newly published study of Texas school district data and industrial mercury-release data, conducted by researchers at The University of Texas Health Science Center at San Antonio, indeed shows a statistically significant link between pounds of industrial release of mercury and increased autism rates. It also shows—for the first time in scientific literature—a statistically significant association between autism risk and distance from the mercury source.
“This is not a definitive study, but just one more that furthers the association between environmental mercury and autism,” said lead author Raymond F. Palmer, Ph.D., associate professor of family and community medicine at the UT Health Science Center San Antonio. The article is in the journal Health & Place.
Dr. Palmer, Stephen Blanchard, Ph.D., of Our Lady of the Lake University in San Antonio and Robert Wood of the UT Health Science Center found that community autism prevalence is reduced by 1 percent to 2 percent with each 10 miles of distance from the pollution source.
