All Posts Tagged With: "Lipoic acid"

Vitamin deficiency and age-related disorders

Triage theory by world famous Bruce Ames explains why I am getting younger by the year. This world-class biochemist has provided the scientific documentation that we all have some small inborn errors of metabolism so we are not operating at our peak if we settle for RDA level of nutrients. His earlier work has provided the scientific framework validating my years of work in Orthomolecular Medicine. Now he has taken his tremendous knowledge of nutrition and has seen how this ties into mitochondrial diseases and aging.

This is the tip of the iceberg. You need to search on Bruce Ames and his close associate Les Packer PhD who have also explained how and why we need CoQ and Carnitine and the all R form of Lipoic acid if it is fully stabilized, to see age reversal in old rats. See his full page ad in every issue of Scientific America and learn more about why I do not just have rich urine when I take my multiple supplements each day. See my personal nutrition program on my website. 

For many Professor Ames needs no introduction. In the 1970s, he invented the Ames test, a simple and inexpensive assay to check the mutagenicity of compounds. Since then he has dedicated his research to understanding the biochemistry of aging with a focus on mitochondria, the power plants of our cells, as well as how micronutrients may prevent disease, malnutrition, and obesity.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Full article: http://www.nutraingredients.com/Product-Categories/Minerals/Bruce-Ames-Vitamin-insufficiency-boosting-age-related-diseases/?utm_source=Newsletter_Product&utm_medium=email&utm_campaign=Newsletter%2BProduct

Excerpt:

It is literally all about living for today. By understanding that nature favours survival today over tomorrow, a theory that vitamin inadequacy is behind the rise in chronic diseases “makes sense… and it is almost certainly going to be right,” says world-renowned scientist Bruce Ames. 

In an exclusive interview with Stephen Daniells, Professor Bruce Ames from the University of California, Berkeley explains why his “triage theory” could have enormous implications for human health. 

For many, Professor Ames needs no introduction. In the 1970s, he invented the Ames Test, a simple and inexpensive assay to check the mutagenicity of compounds. Since then he has dedicated his research to understanding the biochemistry of ageing, with a focus on mitochondria, the power plants of our cells, as well as how micronutrients may prevent disease, malnutrition, and obesity. 

So, when the native New Yorker with over 450 scientific publications tells you his triage theory is “the most important thing I have ever worked on”, you sit up and listen. 

Evolutionary mechanisms 
Triage – from the French word trier meaning to sort, separate, or select – works on the battlefield by military doctors prioritising treatments depending on the probable survival of the wounded. 

Prof Ames’ theory works in much the same way: By appreciating that natural selection favours short-term survival over the long-term, Prof Ames’ hypothesised that our short-term survival is achieved by prioritising the allocation of scarce micronutrients. In other words, to stop us falling over from a lack of iron in the heart, for example, iron is pulled from non-essential sources. 

Plasma Pharmacokinetics of R-(+)-Lipoic Acid – Dr. Gordon & Linda comment

Linda’s comment:  Zeo Gold ROCKS….I have been taking Zeo Gold fromwww.longevityplus.com since it came out….I started with the ACZnano Zeolite, which binds in the body so it doesn’t bounce back, then I graduated to the Zeo Gold, but still take 5 sprays 4-5 times daily of the ACZnano Zeolite….This product is everything that Dr Gordon says it is….I won’t be without it…Both of these are part of the FIGHT protocol and I have been dissolving biofilms using the FIGHT  protocol….

Zeo Gold works on everyone due to the SYNERGY of its world class ingredients. There are extensive research papers on each ingredient that stand alone as proven effective so taken all together you may feel years younger in a few weeks.

YOU will want to work to higher doses slowly to increase the effects you feel; toxins took years to accumulate and this just gets better and better. You will be getting rid of toxins and the fecal changes alone will amaze you at higher doses, as the Biofilm is changed. 

How is ZEO GOLD changing lives? It has set a new standard for effective lifetime detoxification that you feel, and can see, and document increased exercise tolerance, memory, aches and pains gone. There is nothing that does not improve from sexual energy to sleep patterns, as you really lower all toxins in your body, not just lead. 

The synergy from the five proven ingredients is just part of the story; each ingredient is also the best in its class! The exciting feedback from users of Zeo Gold tells us that this product is a home run. 

The active ingredients in Zeo Gold include the most advanced form of Lipoic acid available anywhere. Zeo Gold contains an advanced form of Lipoic acid shown to absorb 21 times better. When you understand the proven benefits of Lipoic acid you will not go a day without taking the best. I am sure that you are not getting this form of Lipoic acid now.  This form changes everything.  (Alpha Free, Synthetic Free). 

The University of Pennsylvania has proven that some forms of oral Glutathione are effective, not a waste as many continue to mistakenly believe. 

The Humic Acid in ZeoGold is premium Grade which has been the subject of extensive scientific research and has been shown to aid the body’s ability to maintain overall health. The Zeolite sets new standards for efficacy, as it provides at least 10 times the surface area of any other zeolite for human consumption available anywhere. 

The Ascorbic Acid is the world‘s leading Vitamin C product, BioEn’R-G’y C with METHYLATION factors (MSM, TMG) and more.

If you are not treating yourself and your family with this product, you are wasting valuable time as it takes time to increase the dose since there are real changes in your stool frequency for the first two plus months as toxins leave.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Excerpt:

Research Abstract
BACKGROUND: The racemic mixture, RS-(+/-)-alpha-lipoic acid (rac-LA) has been utilized clinically and in a variety of disease models. Rac-LA and the natural form, R-lipoic acid (RLA), are widely available as nutritional supplements, marketed as antioxidants. Rac-LA sodium salt (NaLA) or rac-LA potassium salt (KLA) has been used to improve the aqueous solubility of LA. 

STUDY RATIONALE: Several in vitro and animal models of aging and age-related diseases have demonstrated efficacy for the oral solutions of LA salts in normalizing age-related changes to those of young animals. Other models and studies have demonstrated the superiority of RLA, the naturally occurring isomer over rac-LA. Despite this, RLA pharmacokinetics (PK) is not fully characterized in humans, and it is unknown whether the concentrations utilized in animal models can be achieved in vivo. Due to its tendency to polymerize, RLA is relatively unstable and suffers poor aqueous solubility, leading to poor absorption and low bioavailability. A preliminary study demonstrated the stability and bioavailability were improved by converting RLA to its sodium salt (NaRLA) and pre-dissolving it in water. The current study extends earlier findings from this laboratory and presents PK data for the 600-mg oral dosing of 12 healthy adult subjects given NaRLA. In addition, the effect of three consecutive doses was tested on a single subject relative to a one-time dosing in the same subject to determine whether plasma maximum concentration (Cmax) and the area under the plasma concentration versus time curve (AUC) values were comparable to those in animal studies and those achievable via intravenous infusions in humans. 

METHODS: Plasma RLA was separated from protein by a modification of a published method. Standard curves were generated from spiking known concentrations of RLA dissolved in ethanol and diluted in a phosphate-buffered saline (PBS) into each individual’s baseline plasma to account for inter-individual differences in protein binding and to prevent denaturing of plasma proteins. Plasma RLA content was determined by the percent recovery using high-performance liquid chromatography (electrochemical/coulometric detection) (HPLC/ECD). 

RESULTS: As anticipated from the preliminary study, NaRLA is less prone to polymerization, completely soluble in water, and displays significantly higher Cmax and AUC values and decreased time to maximum concentration (Tmax) and T1/2 values than RLA or rac-LA. In order to significantly extend Cmax and AUC, it is possible to administer three 600-mg RLA doses (as NaRLA) at 15-minute intervals to achieve plasma concentrations similar to those from a slow (20-minute) infusion of LA. This is the first study to report negligible unbound RLA even at the highest achievable plasma concentrations.
(Altern Med Rev 2007;12(4):343-351)

Lipoic Acid: New Research & the New Paradigm

Linda’s comments:  ZeoGold is a very important part of the FIGHT program.  I take it daily.  In fact during the testing period I took as much as one teaspoon of ZeoGold daily.  I take this with one teaspoon=4000mg of the BioEnergyC.  I also take three additional teaspoons of BioEnergy C throughout the day.  I again urge each and everyone of you to study the FIGHT program.  I have been on the FIGHT program 1 1/2 years now, with GREAT results.  Even though I’m taking the ZeoGold, I continue to take 5 sprays, 3x’s daily and sometimes more of the ACZnano Zeolite.