All Posts Tagged With: "biopsies"

PSA Rise as Cancer Predictor – with Dr. Gordon’s Comments

Dr. Gordon’s Comments:

PSA level velocity is a red herring; another myth about cancer diagnosis and treatment falls apart. How many men have lived in fear for years and some have had multiple biopsies, which I do not order for my patients because prostate cancer is the easiest of all cancers to treat with natural products.

– the “velocity” of rising PSA has needlessly tripled the biopsy rate providing risk without benefit for patients”

Since biopsies are now known to help spread cancer, the benefit to risk ratio for 2 out of 3 biopsies is  clearly negative. What we need, of course, is something that motivates people to follow a health promoting life style. I have called my life style program F.I.G.H.T. It is based on Dr Kobayashi’s ten years of research where some ten thousand patients avoided death from cancer.

It proved that cancer level in our body invariably diminishes with the simple health promoting steps he developed, which lead to my developing the F.I.G.H.T. program. It is important that these steps are initiated before the lump/bump stage develops. This proves that all cancer tests have some potential benefit to motivate patients to improve their health but only if we can limit the damage that overly aggressive treatment can lead to, including unwarranted biopsies. Cancer is a systemic disease and attacking the prostate or whatever tissue seems to be the focus is not the answer.

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Link: http://yourlife.usatoday.com/health/medical/cancer/story/2011/02/Study-PSA-rise-not-good-prostate-cancer-predictor/44135930/1

Excerpt:

Study: PSA rise not good prostate cancer predictor
Updated Feb 24, 2011 5:58 PM |

A rising PSA level isn’t such a good a predictor of prostate cancer after all, and can lead to many unnecessary biopsies, says a large new study.

Most men over 50 get PSA blood tests, but they’re hugely problematic. Too much PSA, or prostate-specific antigen, only sometimes signals prostate cancer is brewing — it also can mean a benign enlarged prostate or an infection. And screening often detects small tumors that will prove too slow-growing to be deadly. Yet there’s no sure way to tell in advance who needs aggressive therapy.

On the other hand, some men have cancer despite a “normal” PSA count of 4 or below. So for PSAs that are rising, yet still in the normal range, some guidelines urge doctors to consider a biopsy.

How quickly the PSA number rises is something “that patients and doctors worry a lot about,” said Dr. Andrew Vickers of Memorial Sloan-Kettering Cancer Center. “Men show up here with a PSA of 2 and we say, ‘Why are you here?’ And they say, ‘Well, I used to be a 1 and my doctor’s worried. Am I going to die?'”

So Sloan-Kettering researchers studied whether considering PSA velocity adds value to the biopsy-or-not decision in those otherwise low-risk men — and concluded it doesn’t.
“This is a really important study,” said Dr. Otis Brawley of the American Cancer Society, who wasn’t part of the research. “A lot of doctors are going to stop looking at a PSA rise of 1 and ordering biopsies.”

Dr. Gordon comments on PSA surveillance

Dr. Gordon’s Comments:

This article can be helpful if you understand how I would use PSA information and what I believe active surveillance should entail. I want to keep my patients away from needless, often repeated, biopsies and other far too aggressive prostate treatments.

I find it useful, as usually we can at least modulate PSA doubling time, as the pomegranate study proved. So I like my patients to have something that helps them focus on staying healthy but to me that is total health not just excess focus on the prostate but even looking at bone density and coronary calcification and/or premature aging etc.

Tests help me to reward patients who follow my FIGHT program, as everything I test should be able to improve overtime even though the patients is getting older. I find patients with some significant health concern that can be retested over time and show subsequent improvement in those repeated tests will really do what I consider to be an adequate LIFELONG health and life style program, as called for with my FIGHT program working on all levels.

At most 12% of all prostate cancers seem to ever become significant threats to the patient’s long term survival. As we age eventually everyone has some prostate cancer, so how to protect the patients so they are not suddenly confronted with metastatic disease and do this without the nonsense of up to eight repeated biopsies over the course of a few years, is where the ART of medicine comes in.

We know that Dr Black at Dartmouth years ago proved that by age 60, autopsies find cancer of the prostate in 60% of all subjects tested. So with elevated PSA test, I like to do other tests such as caprofile.net for $371, as that picks up many cancers and tells you who has elevated anaerobic metabolism going on (Warburg Nobel prize, cancer is anaerobic). Also I like to consider the concept we learn from the Kobayashi Cancer Panel of tests, where he proved that ALL early cancers suggested by tumor tests would normalize with adequate life style based programs. So our goal is to put a program together that will in time invariably lead to normalization of those tests.

The developer of the PSA test now claims it never was intended as a cancer test, but more to detect chronic prostatitis so I believe that infection is a key part of my fIght program and things like local hyperthermia and ACS 200 silver etc should help us overcome this
condition.

But I use any abnormal test as a motivator to improve health and expect all future retesting to improve everything from testosterone levels to liver function tests and levels of toxins in the body. So it comes down to my interpretation of the term active surveillance where I am focused on Anti-aging medicine and helping my patients reach their maximum intended useful lifespan. Any tests that are not optimal I use to encourage patients to adopt any and all modalities including Heparin, Vitamin C, Wobenzym, Quercetin, Ozone/Ultraviolet Blood Irradiation, meditation, diet changes, etc.

I like to do broader testing and I can usually find some other areas in my PSA patient’s work-up needing optimization, i.e. blood flow to heart, brain function, memory, exercise tolerance, glucose control etc. So, for me, PSA testing and follow up fits into a broad program of monitoring, as many things as patients are willing to look at and devising a program for my patients that will optimize everything always. We know that a few cases of prostate cancer can seem very aggressive and lead the patient to their demise. If patients knew the truth however that according to oncology literature in USA, stage 4 cancers have only a 2.1% five year survival with mainstream treatment, but using alternative approaches Doctor Forsythe, an oncologist in Reno, has documented to FDA who went through all his records that he has 500 stage 4 cancer patients that includes all types of cancer – with his 5 year survival being 37.5%.

And, in my experience, with stage 4 wide spread ca of the prostate, it is the easiest one of all to treat for severe widespread mets. I like things like hyperthermia but just using IV Vitamin C and anticancer plants like Laetrile and Enzymes like Wobenzym that I used in my running the Manner Clinic in Tijuana I have always found prostate cancer to be very responsive to non drug therapy at any stage.

Meantime, since with my current age of 75, I should expect that I have a 75% probability of having it, yet the life style program I follow to deal with all of my other issues, like CV disease etc, my prostate is well controlled. Thus always remember my FIGHT program. I am convinced 99% of all patients will do well on this plus non toxic plant based support particularly if we begin my program before we have detectable lump/bump disease or wide-spread mets.

Please note the conclusion of this new research paper that can save thousands of patients who are now  hapless victims of overaggressive prostate treatments widely given in our country all too often I fear for  the benefit of the treating doctor, not for the patient.

“This means that many men with low-risk prostate cancer are receiving aggressive cancer treatment even though active surveillance may be a safer and acceptable alternative for some men with PSA levels below 10 ng/mL.1”

Garry F. Gordon MD,DO,MD(H)
President, Gordon Research Institute
www.gordonresearch.com

Link: http://www.nhiondemand.com/HSJArticle.aspx?id=913&utm_source=NHI+OnDemand+Newsletter+List&utm_campaign=a61eed16f7-HSJ_Sep30_2010&utm_medium=email

Excerpt:

Date: 9/28/2010
Over Diagnosis and Overtreatment for Prostate Cancer.
Source: Archives of Internal Medicine

Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers. The cancer cells may metastasize (spread) from the prostate to other parts of the body, particularly the bones and lymph nodes. Prostate cancer may cause difficulty urinating, urinary retention, problems during sexual intercourse, or erectile dysfunction. Other symptoms can potentially develop during later stages of the disease such as fatigue, nausea, weakness, back pain, swollen lymph nodes, discomfort in the perineum, hip pain, or weight loss. Blood may be present in the urine. Most prostatic cancers are detected in asymptomatic men who have an elevated PSA (Prostate Specific Antigen) level or a nodular or enlarged prostate at the time of examination.

Prostate cancer screening is utilized to detect the tumor while it is localized in the prostate and is most easily and successfully treated. Biopsy of the prostate is essential for establishing the diagnosis and is indicated when an abnormality is detected by palpation or elevated PSA. 

Recent data suggests that prostate cancer screening may lead to over treatment in men who do not actually need any cancer treatment. The study reviewed information from 123,934 men with newly diagnosed prostate cancer. Researchers found that 14 percent had PSA values below 4 ng/mL, 73.5 percent were between 4.1 and 20 ng/mL and 12.5 percent had levels above 20 ng/mL. Men with screen-detected prostate cancer and PSA values less than 4 ng/mL were 1.49 and 1.39 times more likely to receive radical prostatectomy and radiation therapy, respectively, and were less likely to have high-grade disease than men who had non-screen-detected prostate cancer. This means that many men with low-risk prostate cancer are receiving aggressive cancer treatment even though active surveillance may be a safer and acceptable alternative for some men with PSA levels below 10 ng/mL.1

1 Shao YH, Albertsen PC, Roberts CB, et al. Risk profiles and treatment patterns among men diagnosed as having prostate cancer and a prostate-specific antigen level below 4.0 ng/ml. Arch Intern Med. 2010;170(14);1256-61.

Bartonella henselae neuroretinitis in a 15-year-old girl

A 15-year-old girl being treated with imatinib for chronic myelogenous
leukemia (CML) presented with acute vision loss in her right eye
accompanied by swelling of the right side of her neck. On examination,
she was found to have disk and macular edema of the right eye.
Fine-needle aspiration and excisional biopsies of an enlarged
submandibular lymph node were negative for malignancy. Although initial
serologies were equivocal for Bartonella henselae, repeat serologies
performed 1 week later upon the appearance of a macular star were
positive. This is the first reported case of B. henselae in a patient
with CML. Continued

Lyme pericarditis leading to tamponade

We report the case of a 62-yr-old man who presented with Lyme pericarditis leading to cardiac tamponade shortly followed by an arthritis. IgM and IgG antibodies to Borrelia burgdorferi were demonstrated in serum by indirect immunofluorescence. Borrelia burgdorferi was demonstrated and identified in pericardial fluid by indirect immunofluorescence using serum from a patient with proven Lyme disease and by a monoclonal antibody immuno-gold silver stain. Spirochetes were also found in synovial biopsies using a silver stain. The tamponade was treated with pericardiocentesis; the arthritis was treated with intravenous ceftriaxone (2 g once daily) for 14 days. The patient recovered completely within days of commencing treatment. This case report demonstrates that borrelial infection may lead to pericarditis and cardiac tamponade. Continued

Spirochetes in cardiac biopsies

Linda’s comment:  This report was posted in 1989 but it still is true today.  Many of us Lymies have/had Lyme Carditis.  It can be frightening to say the least.  I was never one to do antibiotics, but I did plenty of anti microbial’s, herbals, supplements and later the FIGHT lifelong daily detox and don’t have those problems today.  Reducing heavy metals and reducing my total body burden of pathogens and toxins has been God sent to me.  You don’t have to use the brands that I chose, but I know the products I used worked, and are still working for me.   I have battled (5) Cancers, (2) Lyme infections, COPD, Arthritis, CHF, Varestrongylus Klapowi worm, and several other health woes, however once I woke up and made the right lifestyle changes, the battles I fought became much easier.  Giving up GMO foods, removing all the toxins,chemicals, pesticides, herbicides, and toxic cleaning supplies from my home made this healing and detox journey much easier. Being a southern cook, it wasn’t as hard as I anticipated to make cooking changes.  My recipes have become just as delicious.  Did I complain when making these changes, you betcha I did.  However, when I begin my research on all the no no’s in my life and finding out the Cancers were environmental Cancers, threw me right into the mission of making changes.  Once I stopped complaining to my self it was much easier.  It became a challenge to prove to myself I could make these changes.  In the beginning I never told my family that they were eating gluten free or Buffalo meat.  When they began to tell me that they knew something was different, but it tasted good to them, I finally admitted about the gluten free and Buffalo. Regards, Linda

Cardiac involvement occurring early in Borrelia burgdorferi infection is a clinical manifestation of human Lyme disease. Therefore, two patients with acute complete atrioventricular heart blocks and unexplained recurrent dizziness were studied. Both patients had significantly elevated serum titers of IgM and IgG antibodies to B. burgdorferi. Right ventricular subendocardial biopsies showed dense infiltrates consisting of lymphocytes and plasma cells. Silver staining revealed spirochetes characteristic of B. burgdorferi near and in the infiltrates, between the muscle fibers, and in the endocardium. One patient responded to penicillin; the other did not, necessitating installation of a pacemaker. Thus, permanent heart damage may result from cardiac involvement in Lyme disease. Continued