All Posts Tagged With: "antibodies"

Link: http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21117995&retmode=ref&cmd=prlinks

Excerpt:

Results-Sensitivity and specificity of the in-clinic ELISA for detection of
heartworm antigen (99.2% and 100%, respectively), antibodies against B
burgdorferi (98.8% and 100%, respectively), and antibodies against E canis
(96.2% and 100%, respectively) were similar to results for a similar
commercial ELISA. In samples obtained from dogs in the northeast and upper
Midwest of the United States, sensitivity and specificity of the in-clinic
ELISA for antibodies against Anaplasma spp were 99.1% and 100%,
respectively, compared with results for an immunofluorescence assay. Samples
from 2 dogs experimentally infected with the NY18 strain of A
phagocytophilum were tested by use of the in-clinic ELISA, and antibodies
against A phagocytophilum were detected by 8 days after inoculation.
Antibodies against Anaplasma platys in experimentally infected dogs
cross-reacted with the A phagocytophilum analyte. Coinfections were
identified in several of the canine serum samples. 
Conclusions and Clinical Relevance-
The commercially available in-clinic ELISA could be used by veterinarians to
screen dogs for heartworm infection and for exposure to tick-borne
pathogens.

Excerpt:

RESULTS: Antibodies were detected in all evaluated groups. In
group of neuroborreliosis (lymphocytic meningitis with cranial
nerve invoIvement) there was no essential difference with control
group.
It was stated in group of forestry workers with serological
features of infection B. burgdorferi lasting for years.
CONCLUSIONS: Results of the study do
not support the thesis of participation of IgG autoantibodies
against gangliosides in pathogenesis early disseminated Lyme
borreliosis in form of lymphocytic meningitis with cranial nerves
paresis. Antibodies against endogenous glicosfingolipides in Lyme
borreliosis probably can lead to affecting nervous system
(demielinisation and polineuropathy) but probably require
long-term immunization, what is suggested by results of examined
group of patients with the multi-annual serological features of
infection.

Vitamin B12 deficiency is EPIDEMIC and we suffer from this lack of B12 with many health problems including fatigue and early memory loss. This report found that 50% of TYPE 2 Diabetics have B-12 deficiency, which contributes to the more rapid development of diabetic complications including dementia and neuropathy.

It is so easy to correct this condition using Longevity Plus’s sublingual Beyond B12, which includes the ideal form of B12 Methylcobalamin to support methylation, as well as ACTIVE forms of Folic Acid. Folic acid is also so vital for health and again when properly tested, 5’MTHF is almost routinely deficient in our aging population.

Full article:

Excerpt: http://www.liai.org/

Finding has major implications for efforts to develop a first-ever vaccine against the dangerous infectious disorder

SAN DIEGO – (February 11, 2010) A leading immunology research institute has validated the long-held and controversial hypothesis that antibodies – usually the “good guys” in the body’s fight against viruses – instead contribute to severe dengue virus-induced disease, the La Jolla Institute for Allergy & Immunology announced today. The finding has major implications for the development of a first-ever vaccine against dengue virus, a growing public health threat which annually infects 50 to 100 million people worldwide, causing a half million cases of the severest form.

“Our lab has proven the decades old hypothesis that subneutralizing levels of dengue virus antibodies exacerbate the disease,” said La Jolla Institute scientist Sujan Shresta, Ph.D, noting this occurs in people with secondary dengue virus infections who have antibodies to the virus due to a previous infection. “This is a situation where antibodies can be bad for you, which is counter to everything we know about the normal function of antibodies. It also presents a special challenge for researchers working to develop a dengue virus vaccine, since most vaccines work by prompting the body to produce antibodies.”

 Background: Previous research suggests that low serum concentrations of
the third component of complement (C3) are associated with both the
susceptibility to infectious agents such as Borrelia burgdorferi and the
development of glomerular disease. We hypothesized that low levels of C3
are associated with the coincident occurrence of B. burgdorferi
infection and glomerulonephritis in Bernese Mountain dogs. Continued

OBJECTIVE: Recent studies have suggested an important role of the B-cell chemoattractant CXCL13 in acute neuroborreliosis (NB). Our aim was to confirm the diagnostic role of CXCL13 and to evaluate its relevance as a therapy response and disease activity marker in NB. Continued