Common gut bacteria can induce eukaryotic chromosomal instability in vivo, according to a study published in a recent issue of the Proceedings of the National Academy of Sciences USA.Up to 34% of commensal Escherichia coli strains isolated from human faeces in high-income countries contain pks, a genomic island encoding a cluster of non-ribosomal peptide synthetases and polyketide synthetases that are involved in the production of the genotoxin colibactin.
In this study, we evaluated Amblyomma americanum (lone star tick)
in Mississippi for the presence of Ehrlichia chaffeensis,
causative agent of human monocytic ehrlichiosis; Ehrlichia
ewingii, causative agent of human and canine granulocytic
ehrlichiosis; Borrelia lonestari, putative agent of southern
tick-associated rash illness; Francisella tularensis, the agent
of tularemia; and Rickettsia spp., particularly R. amblyommii, a
suspected pathogen. We collected adult A. americanum from four
regions of Mississippi: Northeast, Northwest, Southeast, and
East. Of the ticks collected, 192 were dissected and DNA was
extracted for nested polymerase chain reaction (PCR) assays to
detect the above bacteria. In all, 3% of tick extracts had
evidence of Borrelia sp., 4% for E. chaffeensis, 6% for E.
ewingii, and 44% for a Rickettsia species. As determined by
sequencing, most Rickettsia spp. were R. amblyommii. In addition,
extracts from 42 pools (total of 950) of larval A. americanum
collected in Southwest Mississippi were tested for the presence
of E. chaffeensis and Rickettsia species. Of these extracts from
pools, nine of 37 (24%) were PCR positive for a Rickettsia sp.,
most often, R. amblyommii; none had evidence of E. chaffeensis,
supporting the ability of lone star ticks to transovarially
transmit R. amblyommii, but not E. chaffeensis. This study
demonstrates E.
Intracellular Pathogens Research Laboratory, Center for
Comparative Medicine and Translational Research, College of
Veterinary Medicine, North Carolina State University, Raleigh, NC
(E.B. Breitschwerdt, R.G. Maggi, P. E. Mascarelli), and the
Department of Pathology, North Shore University Hospital, 300
Community Drive, Manhasset, New York (P. Farmer).
Bartonella vinsonii subsp. berkhoffii, Bartonella henselae or DNA
of both organisms was amplified and sequenced from blood,
enrichment blood cultures or autopsy tissues from four family
members. Historical and microbiological results support perinatal
transmission of Bartonella species in this family.
Bartonella vinsonii subsp. berkhoffii, Bartonella henselae or DNA of both organisms was amplified and sequenced from blood, enrichment blood cultures or autopsy tissues from four family members. Historical and microbiological results support perinatal transmission of Bartonella species in this family.
In their publication “Science Now.” Hedging their bets?
Linda’s comment: So as I see it, it is just another pathogen that chronically ill people need to deal with….Is it really a virus, parasite, bacterial????? Don’t feed it, get on the FIGHT program and stop it in its track. All of these critters like the spirochete love feeding off GMO, toxic chemical sweeteners, heavy metals, etc., etc., etc., This gives them their energies/food supply to wreak havoc on our bodies. Healthy people have an advantage over chronic illness. The FIGHT program is one of the best prevention programs I have ever experienced.
Listen up as the XMRV is just one of many new things that are attacking our bodies. Scientists are having a difficult time keeping up with all the new tragedies attacking our bodies because of our toxic environments.
Excerpt:
A theory linking chronic fatigue syndrome (CFS) to an infectious mouse virus known as XMRV has taken a second major hit. First proposed last October in Science, the virus-CFS connection was quickly challenged by a British group. Now a second team of British virologists reports that, after examining tissue from 170 CFS patients, they have failed to find evidence of XMRV.
Patients with CFS often report that their condition–a mix of symptoms including unexplained pains and excessive fatigue–began after an otherwise normal viral infection. And scientists in the past have preliminarily linked CFS to a few viruses. However, those links have fallen apart under scrutiny, and without a firm biological cause for CFS, victims continue to face skepticism that their condition is a “real” disease.
Linda’s comment: Were you aware that formaldehyde converted from the free methyl alcohol embalms living tissue and damages DNA?? Most people don’t realize how dangerous that Aspartame can be. There has been a rise in brain cancers, which we know according to Dr Russell Blaylock, MD, a renowned neuro surgeon. Yet the food industry continue to poison people. However, all the blame can’t be put on the food industry. WE the people need to take the responsibility for buying this deadly neuro poison. If people would stop purchasing the products that contain Aspartame then the industry would change, after all they are in it to make money and don’t give a damn about our health.
I’m as aspartame survivor and trust me people it was UGLY…Listen up and start doing research. Yes we can thank Rumsfeld for making sure this deadly toxin came to market. Right after he slammed it through the FDA, he went to work for Searle….<shaking head>….AND WE T HE PEOPLE let it happen. STOP PURCHASING PRODUCTS WITH THIS DEADLY POISON IN IT…This will get the industry attention. Get into their pocketbook and they will make changes.
The good news is the FIGHT protocol will help you to detox this deadly poison and restore your body back to healthy. I have had tremendous success with the FIGHT protocol and continue to have great results. Don’t delay, start today and you too can enjoy good health again.
What comes to mind is the scripture in Jeremiah that the wicked will
sleep a perpetual sleep and never awaken. Aspartame Disease is now a
heinous global plague causing sickness and death throughout the
world. The history and toxicity of aspartame has reached critical
mass as consumers avoid it like the plague it is. For this reason,
and to erase history, Ajinomoto has changed the name to AminoSweet.
This itself is deceiving since it’s the deadly free methyl alcohol
that sweetens, not the amino acids. Be warned!
Borrelia burgdorferi sensu lato, carried by Ixodes ticks, is one of the
most significant human pathogens responsible for Lyme disease. As there
is no standardized method of polymerase chain reaction (PCR) for
detection and identification of spirochetes’ DNA, we carried out a
comparative analysis using a set of complementary primers for three
regions in the genomic DNA of these bacteria (genes fla, rrs and
non-coding rrs-rrlA region). DNA extracted from 579 Ixodes ricinus ticks
was subjected to nested PCR. DNA of the examined spirochetes was
detected in 43 (7.4 %) lysates when we used fla gene as molecular
marker, in 7 (1.2 %), using primers complementary to the rrs gene, and
in 12 (2.1 %) lysates complementary to the non-coding rrs-rrlA sequence.
Restriction fragment length polymorphism (RFLP) analysis, based on fla
gene, helped identify species from the B. burgdorferi sensu lato (B.
burgdorferi sensu stricto, B. afzelii, B. garinii, B. valaisiana),
detect co-infections, and also identify B. miyamotoi. Therefore the fla
gene is the most sensitive and specific molecular marker for the
detection and identification of Borrelia spirochetes in I. ricinus.
Background: Morphea, granuloma annulare (GA) and lichen sclerosus et atrophicans (LSA) have also been suggested to be linked to Borrelia infection. Previous studies based on serologic data or detection of Borrelia by immunohistochemistry and polymerase chain reaction (PCR) reported contradictory results. Thus, we examined skin biopsies of morphea, GA and LSA by PCR to assess the prevalence of Borrelia DNA in an endemic area and to compare our results with data in the literature.
Methods: Amplification of DNA sequences of Borrelia burgdorferi sensu lato by nested PCR from formalin-fixed and paraffin-embedded skin biopsies of morphea, GA and LSA, followed by automated sequencing of amplification products. PCR-based studies on Borrelia species in these disorders published until July 2009 were retrieved by a literature search. Continued
Central Role of the Holliday Junction Helicase RuvAB in vlsE Recombination and Infectivity of Borrelia burgdorferi
Lyme disease is the most prevalent tick-borne infection in North America and Eurasia. It is caused by the bacterium Borrelia burgdorferi and is transmitted to humans via the bite of infected ticks. These spirochetes can cause both acute and chronic infection and inflammation of the skin, joints, heart, and central nervous system. The persistence of infection despite the presence of an active immune response is dependent upon antigenic variation of VlsE, a 35 kDa surface-exposed lipoprotein. A large number of different VlsE variants are present in the host simultaneously and are generated by recombination of the vlsE gene with adjacent vls silent cassettes. To try to identify factors important in vlsE recombination and immune evasion, we selected mutants in genes involved in DNA recombination and repair and screened them for infectivity and vlsE recombination. Mutants in genes encoding RuvA and RuvB (which act together to promote the exchange of strands between two different DNA molecules) had reduced infectivity and greatly diminished vlsE recombination. In immunodeficient mice, ruvA mutants retained full infectivity, and no vlsE recombination was detected. Our findings reinforce the importance of vlsE variation in immune evasion and persistent infection. Continued
Encephalopathy is like fine art: Most people know it when they see it, but there is very little agreement on how to define it. At the 14th International Lyme Disease Conference, Brian A. Fallon, MD,[1] of Columbia University and the New York State Psychiatric Institute, New York, NY, tried to do just that. More importantly, he described the different ways one can define encephalopathy, the strengths and limitations of each approach, and significantly, what other aspects of life can give the impression of encephalopathy where none exists. First, one must evaluate patients with persistent Lyme encephalopathy by asking the following questions:
Is the diagnosis correct?
Are there comorbid psychiatric disorders that could be treated better? Does the patient have a psychogenic medical illness? What was the patient’s response to prior antibiotics?
Was previous treatment adequate? How long was the course, and what was the route of administration? Was there a subsequent relapse Continued
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Borrelia burgdorferi sensu lato, carried by Ixodes ticks, is one of the
